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Malagashanine (MG) is the parent compound of a new type of indole alkaloids, the N b C(21)-secocuran, isolated so far from the Malagasy Strychnos species traditionally used as chloroquine adjuvants in the treatment of chronic malaria. Previously, it was shown to have weak in vitro intrinsic antiplasmodial activity (ic 50 = 146.5 +/- 0.2 μM), but did display marked in vitro chloroquine-potentiating...
As guided by bioassay to reverse chloroquine resistance in strains ofPlasmodium falciparum , three bisisoquinoline alkaloids pertaining to a novel group, the pavine-benzyltetrahydroisoquinoline dimers, were isolated from stem barks ofHernandia voyronii Jumelle. Their chemical structures were determined by conventional spectral methods assisted by the performance of the 2D NMR techniques, namely COSY...
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