Search results for: Nitin Agrawal

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chapter

A novel filtration approach to create small unilamellar liposomes for drug delivery

Steven A Roberts, Nilay Neelaveni, Nitin Agrawal

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) > 64 - 67

2017 IEEE Healthcare Innovation Point-of-Care Technologies (HI-POCT)

Nanoscale drug carriers have quickly risen to the forefront of translational research and promise to play a prominent role in point of care applications. The protocol for synthesizing these particles typically relies on extensive secondary post processing techniques (e.g. extrusion, dialysis, or ultracentrifugation) that are time consuming and can lead to a net loss in either the number of particles...

chapter

Microfluidic generation of physiological oxygen gradients in vitro

Md. Daud Hossain Khan, Steven A. Roberts, John R. Cressman, Nitin Agrawal

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) > 60 - 63

2017 IEEE Healthcare Innovation Point-of-Care Technologies (HI-POCT)

Cancer progression normally creates intrinsic hypoxic or oxygen gradients within tumor lesions that further instigate metastasis. Despite the advancements, recreating physiological oxygen gradients in vitro remains challenging yet a necessary requirement to develop effective point of care (POC) technologies for elucidating cellular migratory or therapeutic responses for personalized treatments. Here,...

chapter

Enhancing the drug encapsulation efficiency of liposomes for therapeutic delivery

Steven A Roberts, Nitin Agrawal

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) > 136 - 139

2017 IEEE Healthcare Innovation Point-of-Care Technologies (HI-POCT)

Nano-delivery vehicles have been a staple in point of care innovations for nearly two decades. Chief among these are liposomes, which are one of the best developed FDA delivery systems. A critical step of the optimization process is the loading of drugs within the core of the nano-carrier, known as encapsulation. Several procedures have been developed to increase the encapsulation efficiency, however,...

article

Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study

Deepa Haldar, Nitin Agrawal, Seema Patel, Pankaj Ramrao Kambale, more

European Journal of Nutrition > 2018 > 57 > 2 > 703-711

Purpose Polycystic ovarian syndrome (PCOS) is the most common endocrine abnormality among women of reproductive age and is usually associated with oligo-ovulation/anovulation, obesity, and insulin resistance. Hypovitaminosis D may also be a primary factor in the initiation and development of PCOS. However, little is known about the role of genetic variation in vitamin D metabolism in PCOS aetiology...

article

Iris recognition based on sparse representation and k-nearest subspace with genetic algorithm

Ashok K Bhateja, Shikhar Sharma, Santanu Chaudhury, Nitin Agrawal

Pattern Recognition Letters > 2016 > 73 > C > 13-18

Iris recognition has become an important tool for human authentication. An efficient and robust iris recognition model based on sparse representation using compressive sensing and k-nearest subspace (segments) has been proposed; k-nearest subspace approach is used for short listing the classes to reduce the time. The shortlisted candidates are divided into sectors and the sparse recognition is applied...

article

Single-Nucleotide Polymorphism on Exon 17 of Insulin Receptor Gene Influences Insulin Resistance in PCOS: A Pilot Study on North Indian Women

Sukanya Gangopadhyay, Nitin Agrawal, Aruna Batra, Bhaskar Charan Kabi, more

Biochemical Genetics > 2016 > 54 > 2 > 158-168

Polycystic ovarian syndrome (PCOS), a major cause of infertility, is also strongly associated with insulin resistance. Defects in insulin receptor signaling are considered as one of the major molecular pathogeneses for insulin resistance. To investigate the possible mechanism of this signaling defect at genetic level, single-nucleotide polymorphism (SNP) [His 1085 C/T] at the exon 17 of insulin receptor...

article

Parallel multi-objective multi-robot coalition formation

Manoj Agarwal, Nitin Agrawal, Shikhar Sharma, Lovekesh Vig, more

Expert Systems with Applications > 2015 > 42 > 21 > 7797-7811

In the quest for greater autonomy, there is an increasing need for solutions that would enable a large set of robots to coalesce and perform complicated multi-robot tasks. This problem, also known as the multi-robot coalition formation problem has been traditionally approached as a single objective optimization problem. However, robots in the real world have to optimize multiple conflicting criteria...

chapter

Temporal analysis of CTC-endothelium interactions during early metastasis

Steven Roberts, Nitin Agrawal

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) > 1 - 2

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)

Circulation represents one of the most vulnerable stages of the metastatic cascade. Synchronized expression of cell adhesion molecules (CAMs) on circulating tumor cells (CTCs) as well as endothelial cells (ECs) of target organs dynamically regulates CTC-EC adhesion and subsequent extravasation. Due to long time-scales associated with metastatic progression and low concentration of CTCs in blood, understanding...

chapter

An in vitro single cell assay for transendothelial migration of cancer cells

Steven Roberts, Nitin Agrawal

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) > 1 - 3

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)

Metastasis is the leading cause of cancer related deaths. A critical component of metastasis is extravasation, which occurs following the adhesion of circulating tumor cells (CTCs) to the endothelium of target organs. The CTCs migrate through the endothelial layer and dense stroma, guided by an endogenously produced chemotactic gradients. Therefore, transendothelial migration (TEM) is a rate-limiting...

chapter

Building a Delay-Tolerant Cloud for Mobile Data

Shuai Hao, Nitin Agrawal, Akshat Aranya, Cristian Ungureanu

2013 IEEE 14th International Conference on Mobile Data Management > 1 > 293 - 300

2013 14th IEEE International Conference on Mobile Data Management (MDM)

Mobile data usage is on a tremendous rise, due not only to increasing number of users but also to an increase in the number of applications that transfer data over the network. Moreover, applications for sharing, sensing, and collaboration have become more popular, causing significant amounts of data to be generated on devices. Managing this data -- syncing it to the cloud, or with other users or...

chapter

Rectangular Microstrip Patch Antenna with "Pentagonal Rings" Shaped Metamaterial Cover

Bimal Garg, Nitin Agrawal, Vijay Sharma, Ankita Tomar, more

2012 International Conference on Communication Systems and Network Technologies > 40 - 44

2012 International Conference on Communication Systems and Network Technologies (CSNT)

A narrow band micro strip patch antenna with "Pentagonal Rings" shaped metamaterial cover is proposed and analyzed at a height of 3.2mm from the ground plane. The antenna along with the proposed metamaterial cover is designed to resonate at 2.31GHz frequency (in S-Band). Proposed metamaterial cover significantly reduces the return loss and increases the directivity of the antenna in comparison...

chapter

Size reduction of Rectangular Microstrip Patch Antenna incorporated with “INTERCONNECTED FRAMED SHAPED” Metamaterial structure for WLAN applications

Bimal Garg, Vijay Sharma, Nitin Agrawal

2012 IEEE Students' Conference on Electrical, Electronics and Computer Science > 1 - 4

2012 IEEE Students' Conference on Electrical, Electronics and Computer Science (SCEECS)

This work deals with the analysis and simulation of a Rectangular Patch Antenna supported by a “INTERCONNECTED FRAMED SHAPED” Metamaterial structure at a height of 3.2mm from the ground plane and also investigates the potential properties of the proposed antenna. The proposed Antenna is designed at a operating resonant frequency of 4.65GHz to meet WLAN applications. All the simulation work is done...

article

Association of plasma cystatin C levels with angiographically documented coronary artery disease in patients of Indian origin

Aditya Batra, Aditya Kapoor, R.K. Sharma, Nitin Agrawal, more

Journal of Cardiology > 2012 > 59 > 2 > 182-189

Renal impairment in patients with coronary artery disease (CAD) is common and increases morbidity and mortality. Estimation of glomerular filtration rate (GFR) by measuring serum creatinine (Cr) or Cr clearance has limitations. Cystatin C is a novel marker for renal function that is very sensitive and specific for GFR estimation. The utility of plasma cystatin C (PCyC) in patients with CAD needs further...

article

Toxic acute kidney injury

Dharmendra Bhadauria, Nitin Agrawal

Clinical Queries: Nephrology > 2012 > 1 > 1 > 29-33

The kidney is a major organ in the human body carrying out the essential metabolic functions. Metabolism and excretion of exogenously administered therapeutic and diagnostic agents as well as environmental exposures are other major functions of kidneys. Kidney is vulnerable to develop various form of injury via virtue of its role as the primary eliminator of exogenous drugs, and toxins. Toxic kidney...

article

Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization

Xuefei Sun, Ryan T. Kelly, William F. Danielson, Nitin Agrawal, more

ELECTROPHORESIS > 32 > 13 > 1610 - 1618

A novel hydrodynamic injector that is directly controlled by a pneumatic valve has been developed for reproducible microchip CE separations. The PDMS devices used for the evaluation comprise a separation channel, a side channel for sample introduction, and a pneumatic valve aligned at the intersection of the channels. A low pressure (≤3 psi) applied to the sample reservoir is sufficient to drive sample...

article

A Marriage of Convenience

Nitin Agrawal Kapur

Journal of General Internal Medicine > 2010 > 25 > 5 > 480-481

article

Adaptive-Control Model for Neutrophil Orientation in the Direction of Chemical Gradients

Daniel Irimia, Gábor Balázsi, Nitin Agrawal, Mehmet Toner

Biophysical Journal > 2009 > 96 > 10 > 3897-3916

Neutrophils have a remarkable ability to detect the direction of chemoattractant gradients and move directionally in response to bacterial infections and tissue injuries. For their role in health and disease, neutrophils have been extensively studied, and many of the molecules involved in the signaling mechanisms of gradient detection and chemotaxis have been identified. However, the cellular-scale...

article

A Buoyancy-Driven Compact Thermocycler for Rapid PCR

Nitin Agrawal, Victor M. Ugaz

Journal of the Association for Laboratory Automation > 2006 > 11 > 4 > 217-221

We have designed a novel convective flow-based thermocycling system capable of performing high-speed DNA amplification via the polymerase chain reaction in a simplified and inexpensive format. Successful amplification of a 191bp influenza-A target is demonstrated within 25min using a 10μL reaction volume with no modification to standard laboratory protocols. The system is simple to assemble and can...

article

Reactions and Fluidics in Miniaturized Natural Convection Systems

Madhavi Krishnan, Nitin Agrawal, Mark A. Burns, Victor M. Ugaz

Analytical Chemistry > 2004 > 76 > 21 > 6254 - 6265

article

Hierarchical Delay Test Generation

C.P. Ravikumar, Nitin Agrawal, Parul Agarwal

Journal of Electronic Testing > 1997 > 10 > 3 > 231-244

Delay testing is used to detect timing errors in a digital circuit.In this paper, we report a tool called MODET forautomatic test generation for path delay faults in modular combinational circuits. Our technique usesprecomputed robust delay tests for individual modules to computerobust delay tests for the module-level circuit. We present alongest path theorem at the module level ofabstraction which...

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