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Background Hydractinia symbiolongicarpus, a colonial cnidarian, is a tractable model system for many cnidarian-specific and general biological questions. Until recently, tests of gene function in Hydractinia have relied on laborious forward genetic approaches, randomly integrated transgenes, or transient knockdown of mRNAs. Results Here, we report the use of CRISPR/Cas9 genome editing to generate...
Arboviruses are a large group of viruses that are transmitted by arthropods including ticks and mosquitoes. The global diversity of arboviruses is unknown; however, theoretical studies have estimated that over 2,000 mosquito-borne flaviviruses may exist. An increasing number of flaviviruses can only infect insect cells. We hypothesize that insect-specific flaviviruses (ISFVs) represent model genetic...
BackgroundMutations in Surfactant Protein C (SFTPC) can lead to fibrotic interstitial lung disease (ILD) with variable phenotypes, especially in children. The sources of phenotype variability are incompletely understood. A common MUC5B promoter variant rs35705950 is associated with adult Idiopathic Pulmonary Fibrosis (IPF). We examined whether MUC5B is similarly linked to ILD secondary to SFTPC mutations...
The CD8+ T cell responses directed toward the VP1 antigens of human polyomaviruses JC and BK recently were shown to be cross-reactive. Two HLA-A⁎0201-restricted determinants from each virus have been defined and include JCp100–108 (ILMWEAVTL) and BKp108–116 (LLMWEAVTV) as well as JCp36–44 (SITEVECFL) and BKp44–52 (AITEVECFL). We asked whether VP1 from the related SV40 contains similar HLA-A⁎0201-restricted...
Jupiter's low and mid-latitudes are examined using ultraviolet (UV) images obtained with the Hubble Space Telescope Wide Field and Planetary Camera 2 over the period of 1994-1997. Effective atmospheric pressures probed by the F160W, F218W, and F255W are estimated at 100, 165, and 370 mbar, respectively, at low latitudes. Far-ultraviolet images of Jupiter taken with the F160W filter reveal bright and...
Jupiter's polar regions are examined using ultraviolet (UV, 120-320 nm) images obtained with the Hubble Space Telescope Wide Field and Planetary Camera 2 over the period of 1994-1997. These images probe the stratospheric aerosols at pressures of a few tens of millibars. We discovered a UV-darkened segment in the polar shading just equatorward of the north polar hood that remained aligned with the...
Careful examination of 28,460 selected Wide Field and Planetary Camera 2 (WFPC2) long exposures from 1994, 1995, and early 1996 has revealed trails of 96 distinct moving objects. They have been reported to the International Astronomical Union's (IAU) Minor Planet Center for their asteroid database and a few have been identified with known asteroids and used to update their orbits. Most of the objects...
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