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The high rate of mortality and frequent incidence of recurrence associated with hepatocellular carcinoma (HCC) reveal the need for new therapeutic approaches. In this study we evaluated the efficacy of a novel chemoimmunotherapeutic strategy to control HCC and investigated the underlying mechanism that increased the antitumor immune response. We developed a novel orthotopic mouse model of HCC through...
A novel series of 5,7-dibromoisatin analogs were synthesized and evaluated for their cytotoxicities against four human cancer cell lines including colon HT29, breast MCF-7, lung A549 and melanoma UACC903. Analogs 6, 11 and 13 displayed good in vitro anticancer activity on the HT29 human colon cancer cell line in the 1μM range. Analogs 5, 9 and 12, containing a selenocyanate group in the alkyl chain...
The CD8+ T cell responses directed toward the VP1 antigens of human polyomaviruses JC and BK recently were shown to be cross-reactive. Two HLA-A⁎0201-restricted determinants from each virus have been defined and include JCp100–108 (ILMWEAVTL) and BKp108–116 (LLMWEAVTV) as well as JCp36–44 (SITEVECFL) and BKp44–52 (AITEVECFL). We asked whether VP1 from the related SV40 contains similar HLA-A⁎0201-restricted...
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