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We studied the clinical and radiological characteristics of spine involvement in a series of 150 patients with Paget's disease of bone.Spine was involved in 49 of the 150 patients, with a total of 148 vertebrae affected. In 4 patient, involvement was monostotic. In decreasing order, the more frequent localizations were lumbar, thoracic, sacral, and cervical segments. Mixed lesions were predominant,...
We treated 7 patients with Paget's Disease of Bone with a single-day infusion of Pamidronate in 500 mL of serum saline over 12 hours. All patients had active, symptomatic disease with potentially complicating sites of involvement, and were previously unsuccessfully treated with etidronate and calcitonin. Three of the patients presented with moderately active disease (serum alkaline phophatase (AP)...
To study the clinical characteristics of long tubular bone involvement in Paget's disease, we analysed a prospective series of 150 patients.Long tubular bones involved in 54 patients with a total of 80 sites affected. Localization was predominant in the lower extremities (57), fibula and left radius were spared. Mixed osteolytic and osteoblastic pattern were most commonly seen (52). Involvement...
Objective: To describe clinical and radiographic features of pagetic vertebral block.Subjects and Methods: We studied prospectively 190 patients with Paget's Disease of bone. Marcelli's radiographic criteriae were used: 1) Lateral or anterior fusion of vertebral bodies with bone bridging formation between two or more endplates of involved vertebrae; 2) decrease in height of vertebral bodies; 3) Partial...
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