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Focused ultrasound has been shown to interact with Alzheimer's pathology and particularly to trigger the reduction of the amyloid plaque load. However, a less studied interaction is that of ultrasound with the tangle formation that has been implicated in the cognitive decline of Alzheimer's patients. With the current study we investigate the interaction of unilateral focused ultrasound-induced blood-brain...
Focused ultrasound (FUS) with systemically delivered microbubbles has been established to locally, reversibly and non-invasively increase the permeability of the blood brain barrier to facilitate targeted drug delivery to the brain. Despite FUS constituting a promising therapeutic technique, the cellular mechanism of FUS-mediated BBB opening has yet to be fully described. Immunoelectron microscopy...
The brain might be exposed to irradiation under a variety of situations, including clinical treatments, nuclear accidents, dirty bomb scenarios, and military and space missions. Correctly recalling tasks learned prior to irradiation is important but little is known about post-learning effects of irradiation. It is not clear whether exposure to X-ray irradiation during memory consolidation, a few hours...
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