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It has recently become evident that the functional connectome of the human brain is a dynamical entity whose time evolution carries important information underpinning physiological brain function as well as its disease-related aberrations. While simple sliding window approaches have had some success in estimating dynamical brain connectivity in a functional MRI (fMRI) context, these methods suffer...
Recently, the field of functional brain connectivity has shifted its attention on studying how functional connectivity (FC) between remote regions changes over time. It is becoming increasingly evident that the human “connectome” is a dynamical entity whose variations are effected over very short timescales and reflect crucial mechanisms which underline the physiological functioning of the brain....
Parkinson disease (PD) can be considered as a brain multisystemic disease arising from dysfunction in several neural networks. The principal aim of this study was to assess whether large‐scale structural topological network changes are detectable in PD patients who have not been exposed yet to dopaminergic therapy (de novo patients). Twenty‐one drug‐naïve PD patients and thirty healthy controls underwent...
Openness is a personality trait reflecting absorption in sensory experience, preference for novelty, and creativity, and is thus considered a driving force of human evolution. At the brain level, a relation between openness and dopaminergic circuits has been proposed, although evidence to support this hypothesis is lacking. Recent behavioral research has also found that people with mania, a psychopathological...
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