Paul D. Shepard

artykuł

Functional characterization of ether‐à‐go‐go‐related gene potassium channels in midbrain dopamine neurons – implications for a role in depolarization block

Huifang Ji, Kristal R. Tucker, Ilva Putzier, Marco A. Huertas, więcej

European Journal of Neuroscience > 36 > 7 > 2906 - 2916

Bursting activity by midbrain dopamine neurons reflects the complex interplay between their intrinsic pacemaker activity and synaptic inputs. Although the precise mechanism responsible for the generation and modulation of bursting in vivo has yet to be established, several ion channels have been implicated in the process. Previous studies with nonselective blockers suggested that ether‐à‐go‐go‐related...

artykuł

Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia‐related endophenotypes

P. Leon Brown, Paul D. Shepard, Greg I. Elmer, Sara Stockman, więcej

European Journal of Neuroscience > 36 > 6 > 2773 - 2781

Adult rats exposed to the DNA‐methylating agent methylazoxymethanol on embryonic day 17 show a pattern of neurobiological deficits that model some of the neuropathological and behavioral changes observed in schizophrenia. Although it is generally assumed that these changes reflect targeted disruption of embryonic neurogenesis, it is unknown whether these effects generalise to other antimitotic agents...

artykuł

Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia

James I. Koenig, Gregory I. Elmer, Paul D. Shepard, Paul R. Lee, więcej

Behavioural Brain Research > 2005 > 156 > 2 > 251-261

Exposure to stress during gestation induces marked changes in the behavior of the affected offspring. Examining the consequences of prenatal stress may prove useful in understanding more about the origins of schizophrenia because a number of clinical investigations have suggested that developmental insults are associated with an increased incidence of schizophrenia. The purpose of these studies is...

artykuł

Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex

Csaba Kiss, Paul D. Shepard, Ferenc Bari, Robert Schwarcz

Brain Research > 2004 > 1002 > 1-2 > 129-135

Cortical spreading depression (CSD) is characterized by slowly propagating neuronal and astrocytic depolarization, resulting in transient, heightened resistance to subsequent neuronal injury. This study was designed to examine a possible role of the endogenous neuroprotective agent kynurenate (KYNA) in this phenomenon. Unilateral, consecutive CSDs, induced by topical application of 2 M KCl to the...

artykuł

Effects of acute and chronic clozapine on d-amphetamine-induced disruption of auditory gating in the rat

Brian Joy, Robert P. McMahon, Paul D. Shepard

Psychopharmacology > 2004 > 174 > 2 > 274-282

Rationale. Auditory gating deficits observed in patients with schizophrenia have been modeled in animals administered the indirect-acting monoaminergic agonist, d-amphetamine (AMPH). The atypical antipsychotic drug clozapine (CLOZ) reverses the disruption of auditory gating in schizophrenic patients. However, its effects on psychostimulant-induced deficits in animals have yet to be assessed. Objectives...

artykuł

Afferent modulation of dopamine neuron firing patterns

Stephen T Kitai, Paul D Shepard, Joseph C Callaway, Reese Scroggs

Current Opinion in Neurobiology > 1999 > 9 > 6 > 690-697

In recent studies examining the modulation of dopamine (DA) cell firing patterns, particular emphasis has been placed on excitatory afferents from the prefrontal cortex and the subthalamic nucleus. A number of inconsistencies in recently published reports, however, do not support the contention that tonic activation of NMDA receptors is the sole determinate of DA neuronal firing patterns. The results...

artykuł

Effects of the enantiomers of (±)-HA-966 on dopamine neurons: an electrophysiological study of a chiral molecule

Paul D. Shepard, Stephen T. Connelly, Heike Lehmann, Kenneth C. Grobaski

European Journal of Pharmacology > 1995 > 285 > 1 > 79-88

The present study was conducted to evaluate the effects of the resolved enantiomers of (±)-1-hydroxy-3-aminopyrrolidone-2 ((±)-HA-966) on the electrophysiological properties of dopamine-containing neurons in the substantia nigra of the chloral hydrate anesthetized rat. Both (+)- and (-)-HA-966 produced a dose-dependent reduction in firing rate that eventually resulted in total cessation of spontaneous...

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Functional characterization of ether‐à‐go‐go‐related gene potassium channels in midbrain dopamine neurons – implications for a role in depolarization block

Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia‐related endophenotypes

Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia

Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex

Effects of acute and chronic clozapine on d-amphetamine-induced disruption of auditory gating in the rat

Afferent modulation of dopamine neuron firing patterns

Effects of the enantiomers of (±)-HA-966 on dopamine neurons: an electrophysiological study of a chiral molecule

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INFONA - portal komunikacji naukowej

Wyniki wyszukiwania dla: Paul D. Shepard

Functional characterization of ether‐à‐go‐go‐related gene potassium channels in midbrain dopamine neurons – implications for a role in depolarization block

Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia‐related endophenotypes

Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia

Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex

Effects of acute and chronic clozapine on d-amphetamine-induced disruption of auditory gating in the rat

Afferent modulation of dopamine neuron firing patterns

Effects of the enantiomers of (±)-HA-966 on dopamine neurons: an electrophysiological study of a chiral molecule

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