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The cuff electrode provides a stable interface with the peripheral nerve, which has been widely utilized in both basic research and clinical practice over the past few decades. In this paper, we present a microfabricated, parylene-based self-locking cuff electrode. The cuff diameter can be adjusted to accommodate the nerve properly during implantation. This type of cuff electrodes is easy to implant...
We report a parylene-based flexible electroporation chip for in vivo nucleic acid delivery. Benefited from the flexibility of parylene film, our chip fits the natural shape of the electroporated objects, thereby provides a uniform electric field over a large area. In addition, the subject is less likely to be harmed owing to the chip features, including good biocompatibility, less invasive electroporation...
Real-time physiological properties' characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells...
A promising combination of the semiconductor integrated system-on-a-chip (SoC) with the lab-on-a-chip (LOC) is brought in this paper. In this paper, we propose a new technology which enables monolithic integration of the self-assembled biological system, the MEMS structure, the microfluidic system, and CMOS electronic circuits together. Utilizing this approach, more functionality is introduced into...
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