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Interferon-gamma (IFNγ) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Phosphorylated STAT1 homodimers translocate to the nucleus, bind to Gamma Activating Sequence (GAS) and recruit additional factors to modulate gene expression. A bioinformatics analysis revealed that greater number of...
Major histocompatibility complex encoded class I (MHC-I) molecules display peptides derived from endogenous proteins for perusal by CD8 + T lymphocytes. H6, a mouse hepatoma cell line, expresses low levels of surface H-2D d but not H-2K k . Surface H-2D d molecules are unstable and their levels, but not H-2K k , are induced at 22 o C. Immunoprecipitation...
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