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Mitochondrial function depends on the synchronised expression of nuclear and mitochondrial-encoded genes. The expression of many nuclear genes is sensitive to the functional state of mitochondria. Mitochondria containing mutated mtDNA populations have been shown to withstand stress to a high level of tolerance. The prolonged survival of cells that are devoid of mitochondrial DNA is further evidence...
Melanocytes (M) express the nerve growth factor (NGF) receptor, trk A. We found that NGF induces tyrosine (Tyr) phosphorylation of trk A in M within minutes of ligand binding, but interestingly, unlike other transmembrane Tyr kinase receptors that are known to undergo rapid but sustained Tyr phosphorylation, trk A phosphorylation increases with time, suggesting that progressively more receptors become...
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