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Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and CSCs in patients with ovarian carcinoma and showed that MDSCs inhibited T cell activation...
The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) contains multiple acetylation sites, including lysine (K) 39. Mutation of C/EBPβ at K39, an acetylation site in the transcriptional activation domain, impairs transcription of C/EBPβ target genes in a dominant-negative fashion. Further, K39 of C/EBPβ can be deacetylated by HDAC1, and HDAC1 may decrease C/EBPβ-mediated transcription,...
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