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The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) contains multiple acetylation sites, including lysine (K) 39. Mutation of C/EBPβ at K39, an acetylation site in the transcriptional activation domain, impairs transcription of C/EBPβ target genes in a dominant-negative fashion. Further, K39 of C/EBPβ can be deacetylated by HDAC1, and HDAC1 may decrease C/EBPβ-mediated transcription,...