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We present a precise cell trapping platform, structure-confined electrophoresis, which utilize microchannel with lateral cavity to bend the electric field for generating positive dielectrophoresis (DEP) force. A revealed metal electrode, 10µm × 20µm, is placed inside the deep place of cavity. Providing stronger DEP force to trap mobile cells and reducing the flow shear stress acting on the trapped...
This document reports the performance of anti-PSMA monoclonal antibodies in microfludic devices for the isolation of circulating prostate cancer cells.
This paper presents a solution for detecting degradation in electrodes that interface to fluidic or biological systems that forms the basis of numerous actuation and sensing mechanisms in the bio-fluidics field. In this solution, a mid-frequency oscillation test strategy is proposed and evaluated experimentally on an array of electrodes. This technique is based on the sensitivity of the bio-fluidic...
An effective screening test for the early diagnosis of cancer is high on the agenda of oncologists, since early detection increases treatment options and patient prognosis. Using microfluidics and Hyperspectral Imaging Microscopy, we demonstrate the ability to capture and immunophenotype circulating tumor cells (CTCs), which are shed by carcinomas at an early stage and signify the presence of cancer...
Electrodes are fundamental to the reliable operation of a new generation of portable bio-analytical instruments based around microsystems technology. The importance of eliminating false positives and false negatives for these instruments is driving work around embedded test, condition monitoring and both diagnostics and prognostics. This paper proposes two solutions for detecting degradation in electrodes...
A new generation of portable bio-analytical instruments is emerging, in which the analysis is carried out without any (or only minimal) intervention from the operator. To achieve this goal, the system needs to integrate both microfluidics and micro-electronics. The microfluildics are used to extract the sample (bacteria, cells, DNA, etc), carry out the bio-chemistry and deliver the sample to the detector...
The market of microelectronic fluidic arrays for biomedical applications, like DNA determination, is rapidly increasing. In order to evaluate these systems in terms of required design-for-test structures, fault simulations in both fluidic and electronic domains are necessary. VHDL-AMS can be used successfully in this case. This paper shows a highly testable architecture of a DNA bio-sensing array,...
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