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The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. Wider use of next‐generation sequencing made a special provision of the guidelines increasingly pertinent: how to communicate novel HLA alleles. Novel alleles need to be recognized...
We present a catalog of common and well‐documented (CWD) alleles of the German population for the six HLA loci A, B, C, DRB1, DQB1, and DPB1. This study is based on a sample of over 5 million volunteer adult hematopoietic stem cell donors from the 26 German donor centers. To establish the catalog, allele and haplotype frequencies were estimated with a validated implementation of the expectation‐maximization...
For the modernization of its Search & Match Service started in 2016, Bone Marrow Donors Worldwide (BMDW) envisaged to utilize an established HLA matching algorithm. The OptiMatch® search engine for the probabilistic matching of volunteer unrelated stem cell donors to patients in need of transplant was introduced by the German National Bone Marrow Donor Registry (ZKRD) in 2006. In the subsequent...
The completeness and resolution of the HLA typing of registered volunteer donors is usually not sufficient to determine their suitability for a concrete patient. Therefore, knowing the probability for each ambiguity in a donor to turn out to be a match is indispensable for planning the search strategy at large and for deciding each single step.Since the update to version 2 in late 2009, OptiMatch...
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