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ObjectiveThe management of complex patients with neuroimmunological diseases is hindered by an inability to reliably measure intrathecal inflammation. Currently implemented laboratory tests developed >40 years ago either are not dynamic or fail to capture low levels of central nervous system (CNS) inflammation. Therefore, we aimed to identify and validate biomarkers of CNS inflammation in 2 blinded,...
Multiple sclerosis is a disabling neurological disease caused by the demyelination of central nervous system axons. Remyelination and regeneration can occur through the formation of new myelin sheaths by oligodendrocytes, which are recruited as oligodendrocyte progenitor cells (OPCs) after demyelination. The OPC differentiation process can become less effective due to an increase in the environmental...
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