Search results for: Joan Gil

Items from 1 to 20 out of 47 results

article

Male pituitary–gonadal axis dysfunction in post‐acute COVID‐19 syndrome—Prevalence and associated factors: A Mediterranean case series

Oscar Moreno‐Perez, Esperanza Merino, Rocio Alfayate, Maria Eugenia Torregrosa, more

Clinical Endocrinology > 96 > 3 > 353 - 362

Objective Severe acute respiratory syndrome coronavirus 2 through angiotensin‐converting enzyme 2 receptor can harm testes function. The objectives were to analyse the prevalence of low serum testosterone (LT) and impaired fertility potential (Leydig and Sertoli cells dysfunction, respectively) in coronavirus disease 2019 (COVID‐19) male survivors and to evaluate acute infection‐related associated...

article

Clinical Frailty Score vs Hospital Frailty Risk Score for predicting mortality and other adverse outcome in hospitalised patients with COVID‐19: Spanish case series

Jose‐Manuel Ramos‐Rincon, Oscar Moreno‐Perez, Hector Pinargote‐Celorio, Jose‐Manuel Leon‐Ramirez, more

International Journal of Clinical Practice > 75 > 10 > n/a - n/a

Objectives Frailty can be used as a predictor of adverse outcomes in people with coronavirus disease 2019 (COVID‐19). The aim of the study was to analyse the prognostic value of two different frailty scores in patients hospitalised for COVID‐19. Material and Methods This retrospective cohort study included adult (≥18 years) inpatients with COVID‐19 and took place from 3 March to 2 May 2020. Patients...

article

Medium‐term serostatus in Spanish case series recovered from SARS‐CoV‐2 infection

Oscar Moreno‐Pérez, Jose Manuel Ramos, Adelina Gimeno, Juan Carlos Rodríguez, more

Journal of Medical Virology > 93 > 10 > 6030 - 6039

The medium‐term serologic response of SARS‐CoV‐2 infection recovered individuals is not well known. The aims were to quantify the incidence of seropositive failure in the medium term in a cohort of patients with different COVID‐19 severity and to analyze its associated factors. Patients who had recovered from mild and severe forms of SARS‐CoV‐2 infection in an Academic Spanish hospital (March 12–May...

article

Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH‐producing adenomas

Joan Gil, Montserrat Marques‐Pamies, Mireia Jordà, Carmen Fajardo‐Montañana, more

Clinical Endocrinology > 94 > 5 > 811 - 819

Objective Large somatotrophic adenomas depict poor response to somatostatin receptor ligands (SRLs). Debulking has shown to enhance SRLs effect in some but not all cases and tumour volume reduction has been proposed as the main predictor of response. No biological studies have been performed so far in this matter. We aimed to identify molecular markers of response to SRLs after surgical debulking...

article

NOXA upregulation by the prohibitin‐binding compound fluorizoline is transcriptionally regulated by integrated stress response‐induced ATF3 and ATF4

Sonia Núñez‐Vázquez, Ismael Sánchez‐Vera, José Saura‐Esteller, Ana M. Cosialls, more

The FEBS Journal > 288 > 4 > 1271 - 1285

Fluorizoline is a new synthetic molecule that induces p53‐independent apoptosis, in several tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In this study, we describe how fluorizoline induces BCL‐2 homology 3‐only protein NOXA, without modulating the protein levels of anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family members prior to caspase activation, as...

article

Uncontrolled diabetes and health care utilisation: A bivariate latent Markov model approach

Joan Gil, Paolo Li Donni, Eugenio Zucchelli

Health Economics > 28 > 11 > 1262 - 1276

Although uncontrolled diabetes (UD) or poor glycaemic control is a widespread condition with potentially life‐threatening consequences, there is sparse evidence of its effects on health care utilisation. We jointly model the propensities to consume health care and UD by employing an innovative bivariate latent Markov model that allows for dynamic unobserved heterogeneity, movements between latent...

article

Temporary employment, work stress and mental health before and after the Spanish economic recession

Xavier Bartoll, Joan Gil, Raul Ramos

International Archives of Occupational and Environmental Health > 2019 > 92 > 7 > 1047-1059

Purpose This paper analyses the effects of temporary employment on work stress and mental health before (2006/2007) and during the economic recession (2011/2012), and examines whether the economic recession worsened these two health outcomes. Methods To control for selection bias, propensity scores (PS) are computed separately for salaried men and women using microdata from two cross-sectional health...

article

Uncontrolled diabetes and health care utilisation: panel data evidence from Spain

Joan Gil, Antoni Sicras-Mainar, Eugenio Zucchelli

The European Journal of Health Economics > 2018 > 19 > 6 > 785-795

Despite size and relevance of uncontrolled diabetes, robust evidence on its effects on health care utilisation is very limited, especially among European countries. We employed longitudinal administrative data from Spain (2004–2010) to explore the relationship between uncontrolled type 2 diabetes and health care utilisation. We used a biomarker (glycated haemoglobin, HbA1c) to detect the presence...

chapter

Microcirculation of the Lung: Functional and Anatomic Aspects

Joan Gil

Textbook of Pulmonary Vascular Disease > Structure, Function and Regulation > 13-24

The fixed pulmonary vascular anatomy differs from the systemic anatomy in the arrangement and shape of the capillary segments, but an even more striking peculiarity of the lung is that it needs to adapt itself to three different pressures, which leads to considerable adaptations and changes in morphology. Because of the pressure changes required by respiratory mechanics, the morphology differs both...

article

A multi-agent system providing demand response services from residential consumers

E. Karfopoulos, L. Tena, A. Torres, Pep Salas, more

Electric Power Systems Research > 2015 > 120 > C > 163-176

High share of distributed energy resources (DER) into power systems can significantly modify the net demand profile. Error forecasts of intermittent generation of renewable energy sources (RES) along with the current inelastic behavior of the consumption can provoke considerable network operational issues, such as frequency fluctuations and voltage imbalances. Increasing the noncontrollable DER penetration...

article

The influence of obesity and overweight on medical costs: a panel data perspective

Toni Mora, Joan Gil, Antoni Sicras-Mainar

The European Journal of Health Economics > 2015 > 16 > 2 > 161-173

This paper estimates the increase of direct medical costs of both severe and moderate obesity and overweight with respect to a normal-weight individual using a two-part generalised linear model and a longitudinal dataset of medical and administrative records of patients in primary and secondary healthcare centres followed up over seven consecutive years (2004–2010) in Spain. Our findings indicate...

article

Rothia mucilaginosa Pneumonia in an Immunocompetent Patient

Carlos Baeza Martínez, Lucia Zamora Molina, Raquel García Sevila, Joan Gil Carbonell, more

Archivos de Bronconeumologia (English Edition) > 2014 > 50 > 11 > 493-495

Rothia mucilaginosa is a gram-positive coccus that occurs as part of the normal flora of the oropharynx and upper respiratory tract. Lower respiratory tract infections caused by this organism are rare and usually occur in immunocompromised patients. This is the case of an immunocompetent 47-year-old woman with right upper lobe pneumonia in which R. mucilaginosa was isolated in sputum and bronchial...

article

A Trifluorinated Thiazoline Scaffold Leading to Pro‐apoptotic Agents Targeting Prohibitins

Alba Pérez‐Perarnau, Sara Preciado, Claudia Mariela Palmeri, Cristina Moncunill‐Massaguer, more

Angewandte Chemie > 126 > 38 > 10314 - 10318

A new class of small molecules, with an unprecedented trifluorothiazoline scaffold, were synthesized and their pro‐apoptotic activity was evaluated. With an EC₅₀ in the low micromolar range, these compounds proved to be potent inducers of apoptosis in a broad spectrum of tumor cell lines, regardless of the functional status of p53. Fast structure–activity relationship studies allowed the preparation...

article

A Trifluorinated Thiazoline Scaffold Leading to Pro‐apoptotic Agents Targeting Prohibitins

Alba Pérez‐Perarnau, Sara Preciado, Claudia Mariela Palmeri, Cristina Moncunill‐Massaguer, more

Angewandte Chemie International Edition > 53 > 38 > 10150 - 10154

article

YM155 sensitizes ovarian cancer cells to cisplatin inducing apoptosis and tumor regression

Roser Mir, Elisabetta Stanzani, Fina Martinez-Soler, Alberto Villanueva, more

Gynecologic Oncology > 2014 > 132 > 1 > 211-220

The objective of this study is to chemosensitize ovarian cancer (OVCa) cells to cisplatin (CDDP) using an inhibitor of Survivin, YM155. The efficacy of YM155 in combination with CDDP was determined in vitro, ex vivo and in vivo.Human OVCa cell lines A2780p and their cisplatin-resistant derivative A2780cis, were treated with CDDP, YM155, and the combined treatment (YM155+CDDP), and cell viability,...

article

Intergenerational and socioeconomic gradients of child obesity

Joan Costa-Font, Joan Gil

Social Science & Medicine > 2013 > 93 > Complete > 29-37

Can the rise in obesity among children be attributed to the intergenerational transmission of parental influences? Does this trend affect the influence of parent's socioeconomic status on obesity? This paper documents evidence of an emerging social gradient of obesity in pre-school children resulting from a combination of both socio-economic status and less intensive childcare associated with maternal...

article

PEER EFFECTS IN ADOLESCENT BMI: EVIDENCE FROM SPAIN

Toni Mora, Joan Gil

Health Economics > 22 > 5 > 501 - 516

This paper extends the recent literature on the influence of peers on adolescent weight on three new fronts. First, based on a survey of secondary school students in Spain in which peers are formed by nominated classmate friends, we find a more powerful positive and significant causal effect of friends’ mean BMI on adolescent BMI than previous US‐based research. These results are in line with international...

article

Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild‐type ovarian cancer cells

Roser Mir, Avelina Tortosa, Fina Martinez‐Soler, August Vidal, more

International Journal of Cancer > 132 > 7 > 1525 - 1536

Ovarian cancer (OVCa) is the leading cause of death from gynecological malignancies. Although treatment for advanced OVCa has improved with the introduction of taxane–platinum chemotherapy, the majority of patients will develop resistance to the treatment, leading to poor prognosis. One of the causes of chemoresistance is the reduced ability to undergo apoptosis. Cisplatin is a genotoxic drug that...

article

AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts

Diana M. González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M. Cosialls, more

Apoptosis > 2013 > 18 > 8 > 1008-1016

5-Aminoimidazole-4-carboxamide (AICA) riboside (AICAR) is a nucleoside analogue that is phosphorylated to 5-amino-4-imidazolecarboxamide ribotide (ZMP), which acts as an AMP mimetic and activates AMP-activated protein kinase (AMPK). It has been recently described that AICAR triggers apoptosis in chronic lymphocytic leukemia (CLL) cells, and its mechanism of action is independent of AMPK as well as...

article

Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells

Roser Francisco, Alba Pérez-Perarnau, Constanza Cortés, Joan Gil, more

Cancer Letters > 2012 > 318 > 1 > 42-52

Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast,...

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INFONA - science communication portal

Search results for: Joan Gil

Male pituitary–gonadal axis dysfunction in post‐acute COVID‐19 syndrome—Prevalence and associated factors: A Mediterranean case series

Clinical Frailty Score vs Hospital Frailty Risk Score for predicting mortality and other adverse outcome in hospitalised patients with COVID‐19: Spanish case series

Medium‐term serostatus in Spanish case series recovered from SARS‐CoV‐2 infection

Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH‐producing adenomas

NOXA upregulation by the prohibitin‐binding compound fluorizoline is transcriptionally regulated by integrated stress response‐induced ATF3 and ATF4

Uncontrolled diabetes and health care utilisation: A bivariate latent Markov model approach

Temporary employment, work stress and mental health before and after the Spanish economic recession

Uncontrolled diabetes and health care utilisation: panel data evidence from Spain

Microcirculation of the Lung: Functional and Anatomic Aspects

A multi-agent system providing demand response services from residential consumers

The influence of obesity and overweight on medical costs: a panel data perspective

Rothia mucilaginosa Pneumonia in an Immunocompetent Patient

A Trifluorinated Thiazoline Scaffold Leading to Pro‐apoptotic Agents Targeting Prohibitins

A Trifluorinated Thiazoline Scaffold Leading to Pro‐apoptotic Agents Targeting Prohibitins

YM155 sensitizes ovarian cancer cells to cisplatin inducing apoptosis and tumor regression

Intergenerational and socioeconomic gradients of child obesity

PEER EFFECTS IN ADOLESCENT BMI: EVIDENCE FROM SPAIN

Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild‐type ovarian cancer cells

AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts

Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells

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