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The present study aimed to investigate the role played by the leaflets of the plasma membrane in the uptake of drugs into cells and in their extrusion by P‐glycoprotein and multidrug resistance‐associated protein 1. Drug accumulation was monitored by fluorescence resonance energy transfer from trimethylammonium‐diphenyl‐hexatriene (TMA‐DPH) located at the outer leaflet to a rhodamine analog. Uptake...
The objectives of the present work are to characterize the transport of mitoxantrone and three anthracyclines in terms of binding to the membrane surface, flip-flop across the lipid core of the membrane, and release into the medium. Mitoxantrone and anthracyclines are positively charged amphipathic molecules, and as such are located at the surface of membranes among the headgroups of the phospholipids...
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