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Reactive oxygen species participate in regulating intracellular signaling pathways. Herein, we investigated the reported opposite effects of hydrogen peroxide (H2O2) on metabolic signaling mediated by activated α1‐ and β‐adrenoceptors (ARs) in hepatocytes. In isolated rat hepatocytes, stimulation of α1‐AR increases H2O2 production via NADPH oxidase 2 (NOX2) activation. We find that the H2O2 thus produced...
Spatiotemporal regulation of cAMP within the cell is required to achieve receptor‐specific responses. The mechanism through which the cell selects a specific response to newly synthesized cAMP is not fully understood. In hepatocyte plasma membranes, we identified two functional and independent cAMP‐responsive signaling protein macrocomplexes that produce, use, degrade, and regulate their own nondiffusible...
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