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Cell–cell contacts coordinate the endothelial barrier function in response to external cues. To identify new mediators involved in cytokine‐promoted endothelial permeability, we screened a siRNA library targeting E3 ubiquitin ligases. Here, we report that silencing of the late endosome/lysosomal membrane‐associated RING‐CH‐3 (MARCH3) enzyme protects the endothelial barrier. Furthermore, transcriptome...
Background The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators of Kaposi’s sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. The actions of vGPCR manifest pathogenesis, in part, through increased permeability of endothelial cells. Endothelial cell-cell junctions have indeed emerged as an instrumental target involved in the vasculature...
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