Cell Communication and Signaling

article

The epidermal growth factor receptor (EGFR) contributes to efficient entry of influenza A viruses into host cells

T Eierhoff, Er Hrincius, U Rescher, S Ludwig, more

Cell Communication and Signaling > 2009 > 7 > 1 > 1-1

article

Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells and the role of REST

M Ekici, M Hohl, G Thiel

Cell Communication and Signaling > 2009 > 7 > 1 > 1-1

article

The incredible ULKs

Sebastian Alers, Antje S Löffler, Sebastian Wesselborg, Björn Stork

Cell Communication and Signaling > 2012 > 10 > 1 > 1-14

Macroautophagy (commonly abbreviated as autophagy) is an evolutionary conserved lysosome-directed vesicular trafficking pathway in eukaryotic cells that mediates the lysosomal degradation of intracellular components. The cytoplasmic cargo is initially enclosed by a specific double membrane vesicle, termed the autophagosome. By this means, autophagy either helps to remove damaged organelles, long-lived...

article

Erratum to: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Hui Cai, Yan Xu

Cell Communication and Signaling > 2013 > 11 > 1 > 1-2

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The Campylobacter jejuniCiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease

Derrick R Samuelson, Tyson P Eucker, Julia A Bell, Leslie Dybas, more

Cell Communication and Signaling > 2013 > 11 > 1 > 1-15

Background Enteric pathogens utilize a distinct set of proteins to modulate host cell signaling events that promote host cell invasion, induction of the inflammatory response, and intracellular survival. Human infection with Campylobacter jejuni, the causative agent of campylobacteriosis, is characterized by diarrhea containing blood and leukocytes. The clinical presentation of acute disease, which...

article

Zinc inhibits osteoclast differentiation by suppression of Ca²⁺-Calcineurin-NFATc1 signaling pathway

Kwang Hwan Park, Boryung Park, Dong Suk Yoon, Seung-Hyun Kwon, more

Cell Communication and Signaling > 2013 > 11 > 1 > 1-12

Background Zinc, an essential trace element, inhibits osteoclast differentiation in vitro and in vivo. The molecular mechanism for the inhibitory effect of zinc, however, is poorly understood. The purpose of this study was to investigate the effect of zinc and determine its molecular mechanism on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis in mouse bone marrow-derived monocyte...

article

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Hui Cai, Yan Xu

Cell Communication and Signaling > 2013 > 11 > 1 > 1-13

Background The Hippo-YAP signaling pathway is altered and implicated as oncogenic in many human cancers. However, extracellular signals that regulate the mammalian Hippo pathway have remained elusive until very recently when it was shown that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) ligands including lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P). LPA inhibits...

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Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni

Derrick R Samuelson, Michael E Konkel

Cell Communication and Signaling > 2013 > 11 > 1 > 1-15

Background Campylobacter jejuni causes acute disease characterized by severe diarrhea containing blood and leukocytes, fever, and abdominal cramping. Disease caused by C. jejuni is dependent on numerous bacterial and host factors. C. jejuni invasion of the intestinal epithelial cells is seen in both clinical samples and animal models indicating that host cell invasion is, in part, necessary for disease...

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Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

Anne Mohr, Dirk Fahrenkamp, Natalie Rinis, Gerhard Müller-Newen

Cell Communication and Signaling > 2013 > 11 > 1 > 1-12

Background STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution of tyrosine 705 to phenylalanine leads to a dominant-negative STAT3 mutant (STAT3-YF) which influences...

article

Sulindac activates NF-κB signaling in colon cancer cells

Dessislava Mladenova, Laurent Pangon, Nicola Currey, Irvin Ng, more

Cell Communication and Signaling > 2013 > 11 > 1 > 1-16

Background The non-steroidal anti-inflammatory drug (NSAID) sulindac has shown efficacy in preventing colorectal cancer. This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation. We have recently shown that sulindac can cause up-regulation of pro-inflammatory factors in the mouse colon mucosa...

article

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells

Michal Smida, Clemens Cammann, Slavyana Gurbiel, Nadja Kerstin, more

Cell Communication and Signaling > 2013 > 11 > 1 > 1-13

Background PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation. Results PAG-depletion enhanced Src kinase activity and augmented proximal...

article

MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin

Jinsoo Song, Dongkyun Kim, Churl-Hong Chun, Eun-Jung Jin

Cell Communication and Signaling > 2013 > 11 > 1 > 1-13

Background Studies have shown the roles of miR-9 and its validated target, protogenin (PRTG) in the differentiation of chondroblasts to chondrocyte and in the pathogenesis of osteoarthritis (OA). We hypothesized that miR-9 plays a distinct role in endochondral ossification and OA pathogenesis and the present study was undertaken to identify this role. In the studies, chondroblasts were isolated from...

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Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells

Julia Dotterweich, Regina Ebert, Sabrina Kraus, Robert J Tower, more

Cell Communication and Signaling > 2014 > 12 > 1 > 1-12

CCN family member 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), belongs to the extracellular matrix-associated CCN protein family. The diverse functions of these proteins include regulation of cell migration, adhesion, proliferation, differentiation and survival/apoptosis, induction of angiogenesis and cellular senescence. Their functions are partly overlapping, largely...

article

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4 ⁺ T cell effector functions

Natascha Hermann-Kleiter, Gottfried Baier

Cell Communication and Signaling > 2014 > 12 > 1 > 1-12

Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4 ⁺ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor...

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Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells

Vladislav S Golubkov, Alex Y Strongin

Cell Communication and Signaling > 2014 > 12 > 1 > 1-12

Background The full-length membrane protein tyrosine kinase 7 (PTK7) pseudokinase, an important component of the planar cell polarity and the Wnt canonical and non-canonical pathways, is a subject of step-wise proteolysis in cells and tissues. The proteolysis of PTK7 involves membrane type-matrix metalloproteinase (MT1-MMP), members of the Disintegrin Domain and Metalloproteinase (ADAM) family,...

article

Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders

Christine T Wong, Eizaaz Ahmad, Hongyan Li, Dorota A Crawford

Cell Communication and Signaling > 2014 > 12 > 1 > 1-18

Prostaglandin E2 (PGE ₂ ) is a natural lipid-derived molecule that is involved in important physiological functions. Abnormal PGE ₂ signalling has been associated with pathologies of the nervous system. Previous studies provide evidence for the interaction of PGE ₂ and canonical Wnt signalling pathways in non-neuronal cells. Since the Wnt pathway is crucial...

article

The Dictyostelium discoideum RACK1 orthologue has roles in growth and development

Napoleon Nosa Omosigho, Karthic Swaminathan, Markus Plomann, Annette Müller-Taubenberger, more

Cell Communication and Signaling > 2014 > 12 > 1 > 1-18

Background The receptor for activated C-kinase 1 (RACK1) is a conserved protein belonging to the WD40 repeat family of proteins. It folds into a beta propeller with seven blades which allow interactions with many proteins. Thus it can serve as a scaffolding protein and have roles in several cellular processes. Results We identified the product of the Dictyostelium discoideum gpbB...

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High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

Hiroki Sato, Kanako C Hatanaka, Yutaka Hatanaka, Hiromitsu Hatakeyama, more

Cell Communication and Signaling > 2014 > 12 > 1 > 1-9

Background Despite recent advances in cancer therapeutics in general, the survival of patients with head and neck squamous cell carcinomas (HNSCCs) has not improved substantially over the past few decades. HNSCC cells often exhibit invasive and metastatic phenotypes, and expression of epidermal growth factor receptor (EGFR) and cortactin has been highly implicated in the development of malignancy...

article

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

Carla J Aguiar, João A Rocha-Franco, Pedro A Sousa, Anderson K Santos, more

Cell Communication and Signaling > 2014 > 12 > 1 > 1-17

Background Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ischemia increase succinate blood levels, we investigated the role of this metabolite during a heart ischemic...

article

Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells

Lin Chen, Wei Zhang, Hui-fang Liang, Qiao-dan Zhou, more

Cell Communication and Signaling > 2014 > 12 > 1 > 1-14

Background Activin A, an important member of transforming growth factor-β superfamily, is reported to inhibit proliferation of mature hepatocyte. However, the effect of activin A on growth of hepatic progenitor cells is not fully understood. To that end, we attempted to evaluate the potential role of activin A in the regulation of hepatic progenitor cell proliferation. Results Using...

INFONA - science communication portal

Cell Communication and Signaling

The epidermal growth factor receptor (EGFR) contributes to efficient entry of influenza A viruses into host cells

Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells and the role of REST

The incredible ULKs

Erratum to: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

The Campylobacter jejuniCiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease

Zinc inhibits osteoclast differentiation by suppression of Ca²⁺-Calcineurin-NFATc1 signaling pathway

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

Sulindac activates NF-κB signaling in colon cancer cells

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells

MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin

Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4 ⁺ T cell effector functions

Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells

Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders

The Dictyostelium discoideum RACK1 orthologue has roles in growth and development

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells

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