Search results for: Maxwell R. Bennett

Items from 1 to 20 out of 27 results

article

Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth

Maxwell R. Bennett, Leslie Farnell, William G. Gibson

European Journal of Neuroscience > 54 > 1 > 4230 - 4245

The blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) signal arises as a consequence of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen

({CMR}_{O_{2}})

that in turn are modulated by changes in neural activity. Recent advances in imaging have achieved sub‐millimetre resolution and allowed investigation of the BOLD response as a function of cortical...

article

Frontal and subcortical grey matter reductions in PTSD

Daniel C.M. O'Doherty, Ashleigh Tickell, Will Ryder, Charles Chan, more

Psychiatry Research: Neuroimaging > 2017 > 266 > Complete > 1-9

Post-traumatic stress disorder (PTSD) is characterised by a range of debilitating psychological, physical and cognitive symptoms. PTSD has been associated with grey matter atrophy in limbic and frontal cortical brain regions. However, previous studies have reported heterogeneous findings, with grey matter changes observed beyond limbic/frontal areas. Seventy-five adults were recruited from the community,...

article

Hippocampal development in youth with a history of childhood maltreatment

Casey Paquola, Maxwell R. Bennett, Sean N. Hatton, Daniel F. Hermens, more

Journal of Psychiatric Research > 2017 > 91 > C > 149-155

Childhood maltreatment (CM) is associated with enhanced risk of psychiatric illness and reduced subcortical grey matter in adulthood. The hippocampus and amygdala, due to their involvement in stress and emotion circuitries, have been subject to extensive investigations regarding the effect of CM. However, the complex relationship between CM, subcortical grey matter and mental illness remains poorly...

article

Utility of the cumulative stress and mismatch hypotheses in understanding the neurobiological impacts of childhood abuse and recent stress in youth with emerging mental disorder

Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F. Hermens, more

Human Brain Mapping > 38 > 5 > 2709 - 2721

Childhood abuse has an enduring impact on the brain's stress system. Whether the effects of childhood abuse and adulthood stress are additive (cumulative stress hypothesis) or interactive (mismatch hypothesis) is widely disputed, however. The primary aim of this study was to test the utility of the cumulative stress and mismatch hypotheses in understanding brain and behaviour. We recruited 64 individuals...

article

Regulation of fear extinction by long-term depression: The roles of endocannabinoids and brain derived neurotrophic factor

Maxwell R. Bennett, Jonathon Arnold, Sean N. Hatton, Jim Lagopoulos

Behavioural Brain Research > 2017 > 319 > C > 148-164

The extinction of a conditioned fear response is of great interest in the search for a means of ameliorating adverse neurobiological changes resulting from stress. The discovery that endocannibinoid (EC) levels are inversely related to the extent of such stress, and that the amygdala is a primary site mediating stress, suggests that ECs in this brain region might play a major role in extinction. Supporting...

article

Pineal volume and evening melatonin in young people with affective disorders

Joanne S. Carpenter, Amy C. Abelmann, Sean N. Hatton, Rébecca Robillard, more

Brain Imaging and Behavior > 2017 > 11 > 6 > 1741-1750

Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize...

article

Behavior, neuropsychology and fMRI

Maxwell R. Bennett, Sean Hatton, Daniel F. Hermens, Jim Lagopoulos

Progress in Neurobiology > 2016 > 145-146 > C > 1-25

Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the ‘functional magnetic resonance imaging’ (fMRI) method for identifying brain activity. For this research program...

article

Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

Casey Paquola, Maxwell R. Bennett, Jim Lagopoulos

Neuroscience & Biobehavioral Reviews > 2016 > 69 > C > 299-312

Childhood trauma has been associated with long term effects on prefrontal-limbic grey matter. A literature search was conducted to identify structural magnetic resonance imaging studies of adults with a history of childhood trauma. We performed three meta-analyses. Hedges’ g effect sizes were calculated for each study providing hippocampal or amygdala volumes of trauma and non-trauma groups. Seed...

article

Stress, trauma and PTSD: translational insights into the core synaptic circuitry and its modulation

Maxwell R. Bennett, Sean N. Hatton, Jim Lagopoulos

Brain Structure and Function > 2016 > 221 > 5 > 2401-2426

Evidence is considered as to whether behavioral criteria for diagnosis of post-traumatic stress disorder (PTSD) are applicable to that of traumatized animals and whether the phenomena of acquisition, extinction and reactivation of fear behavior in animals are also successfully applicable to humans. This evidence suggests an affirmative answer in both cases. Furthermore, the deficits in gray matter...

article

On explaining and understanding cognitive behaviour

Maxwell R. Bennett, Peter M.S. Hacker

Australian Journal of Psychology > 67 > 4 > 241 - 250

ObjectiveTo show that experimental psychology can correlate physiological events and processes with behavioural manifestations, avowals and reports of thought and experience. MethodConnective analysis. ResultsIt is not necessary to establish a computational theory about the cognitive functions of human beings preparatory to an understanding of the functioning of the brain, for the latter is not...

article

A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

Daniel C.M. O'Doherty, Kate M. Chitty, Sonia Saddiqui, Maxwell R. Bennett, more

Psychiatry Research: Neuroimaging > 2015 > 232 > 1 > 1-33

Posttraumatic stress disorder (PTSD) is a debilitating condition associated with mild to moderate cognitive impairment and with a prevalence rate of up to 22% in veterans. This systematic review and quantitative meta-analysis explore volumetric differences of three key structural brain regions (hippocampus, amygdala and anterior cingulate cortex (ACC)), all of which have been implicated in dysfunction...

article

Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses

Mustafa S. Kassem, Jim Lagopoulos, Tim Stait-Gardner, William S. Price, more

Molecular Neurobiology > 2013 > 47 > 2 > 645-661

Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and to identify the cellular constituents of the grey matter that quantitatively give...

article

Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits

Sean N Hatton, Jim Lagopoulos, Daniel F Hermens, Elizabeth Scott, more

International Journal of Bipolar Disorders > 2013 > 1 > 1 > 1-13

Background People in midlife with established psychosis or bipolar disorder exhibit patterns of cortical thinning across several brain regions. It is unclear whether these patterns are indicative of a continuously active pathological process, residual effects of an earlier illness phase or pre-illness onset developmental risk factors. Here, we investigated whether cortical thinning is evident in younger...

article

Development of ramified microglia from early macrophages in the zebrafish optic tectum

Adam J. Svahn, Manuel B. Graeber, Felix Ellett, Graham J. Lieschke, more

Developmental Neurobiology > 73 > 1 > 60 - 71

Microglia, the resident macrophage precursors of the brain, are necessary for the maintenance of tissue homeostasis and activated by a wide range of pathological stimuli. They have a key role in immune and inflammatory responses. Early microglia stem from primitive macrophages, however the transition from early motile forms to the ramified mature resident microglia has not been assayed in real time...

article

Criminal Law as It Pertains to Patients Suffering from Psychiatric Diseases

Maxwell R. Bennett, Peter M. S. Hacker

Journal of Bioethical Inquiry > 2011 > 8 > 1 > 45-58

The McNaughton rules for determining whether a person can be successfully defended on the grounds of mental incompetence were determined by a committee of the House of Lords in 1843. They arose as a consequence of the trial of Daniel McNaughton for the killing of Prime Minister Sir Robert Peel’s secretary. In retrospect it is clear that McNaughton suffered from schizophrenia. The successful defence...

article

Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

Hendra Gunosewoyo, Mark J. Coster, Maxwell R. Bennett, Michael Kassiou

Bioorganic & Medicinal Chemistry > 2009 > 17 > 14 > 4861-4865

The purinergic P2X ₇ receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.

article

Rottlerin Inhibits (Na⁺, K⁺)-ATPase Activity in Brain Tissue and Alters d-Aspartate Dependent Redistribution of Glutamate Transporter GLAST in Cultured Astrocytes

Khoa T. D. Nguyen, Jae-Won Shin, Caroline Rae, Ellas K. Nanitsos, more

Neurochemical Research > 2009 > 34 > 10 > 1767-1774

The naturally occurring toxin rottlerin has been used by other laboratories as a specific inhibitor of protein kinase C-delta (PKC-δ) to obtain evidence that the activity-dependent distribution of glutamate transporter GLAST is regulated by PKC-δ mediated phosphorylation. Using immunofluorescence labelling for GLAST and deconvolution microscopy we have observed that d-aspartate-induced redistribution...

article

Distribution of Glutamate Transporter GLAST in Membranes of Cultured Astrocytes in the Presence of Glutamate Transport Substrates and ATP

Jae-Won Shin, Khoa T. D. Nguyen, David V. Pow, Toby Knight, more

Neurochemical Research > 2009 > 34 > 10 > 1758-1766

Neurotransmitter l-glutamate released at central synapses is taken up and “recycled” by astrocytes using glutamate transporter molecules such as GLAST and GLT. Glutamate transport is essential for prevention of glutamate neurotoxicity, it is a key regulator of neurotransmitter metabolism and may contribute to mechanisms through which neurons and glia communicate with each other. Using immunocytochemistry...

article

Cubyl amides: Novel P2X7 receptor antagonists

Hendra Gunosewoyo, Jun Liu Guo, Maxwell R. Bennett, Mark J. Coster, more

Bioorganic & Medicinal Chemistry Letters > 2008 > 18 > 13 > 3720-3723

Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X ₇ R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X ₇ selectivity.

article

P2X1 receptor currents after disruption of the PKC site and its surroundings by dominant negative mutations in HEK293 cells

Guo Jun Liu, Jennifer Brockhausen, Maxwell R. Bennett

Autonomic Neuroscience: Basic and Clinical > 2003 > 108 > 1-2 > 12-16

It has been suggested that phosphorylation at the T18P19R20 PKC sites of the P2X1 receptor regulates its functions. Here, we show that mutation at T18 (T18A and T18N) almost abolishes P2X1 current in response to ATP and that mutations of R20T but not of P19V also decrease the P2X1 current. Immunoblotting with anti-Thr(P)-Pro monoclonal antibody of membrane proteins from HEK293 cells transfected with...

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Search results for: Maxwell R. Bennett

Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth

Frontal and subcortical grey matter reductions in PTSD

Hippocampal development in youth with a history of childhood maltreatment

Utility of the cumulative stress and mismatch hypotheses in understanding the neurobiological impacts of childhood abuse and recent stress in youth with emerging mental disorder

Regulation of fear extinction by long-term depression: The roles of endocannabinoids and brain derived neurotrophic factor

Pineal volume and evening melatonin in young people with affective disorders

Behavior, neuropsychology and fMRI

Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

Stress, trauma and PTSD: translational insights into the core synaptic circuitry and its modulation

On explaining and understanding cognitive behaviour

A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses

Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits

Development of ramified microglia from early macrophages in the zebrafish optic tectum

Criminal Law as It Pertains to Patients Suffering from Psychiatric Diseases

Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

Rottlerin Inhibits (Na⁺, K⁺)-ATPase Activity in Brain Tissue and Alters d-Aspartate Dependent Redistribution of Glutamate Transporter GLAST in Cultured Astrocytes

Distribution of Glutamate Transporter GLAST in Membranes of Cultured Astrocytes in the Presence of Glutamate Transport Substrates and ATP

Cubyl amides: Novel P2X7 receptor antagonists

P2X1 receptor currents after disruption of the PKC site and its surroundings by dominant negative mutations in HEK293 cells

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