Search results for: Chun-Hsien Chu

Items from 1 to 20 out of 27 results

article

Physiological Concentration of Prostaglandin E₂ Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway

Shih-Heng Chen, Yueh-Feng Sung, Esteban A. Oyarzabal, Yu-Mei Tan, more

Molecular Neurobiology > 2018 > 55 > 10 > 8001-8013

This study investigated the physiological regulation of brain immune homeostasis in rat primary neuron-glial cultures by sub-nanomolar concentrations of prostaglandin E2 (PGE₂). We demonstrated that 0.01 to 10 nM PGE₂ protected dopaminergic neurons against LPS-induced neurotoxicity through a reduction of microglial release of pro-inflammatory factors in a dose-dependent manner. Mechanistically, neuroprotective...

article

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

Tzu-Yun Wang, Sheng-Yu Lee, Ming-Chuan Hu, Shiou-Lan Chen, more

Psychoneuroendocrinology > 2017 > 85 > C > 42-48

Antisocial personality disorder (ASPD) is highly comorbid with substance use disorders (SUDs). We hypothesize that chronic neuroinflammation and the loss of neurotrophic factors prompts the pathogenesis of both disorders. We used ELISA to measure plasma levels of proinflammatory (tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]) and anti-inflammatory factors (transforming growth factor-β1...

article

Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals

Chun-Hsien Chu, Shijun Wang, Chia-Ling Li, Shih-Heng Chen, more

Brain, Behavior, and Immunity > 2016 > 55 > C > 260-272

Endotoxin tolerance (ET) is a reduced responsiveness of innate immune cells like macrophages/monocytes to an endotoxin challenge following a previous encounter with the endotoxin. Although ET in peripheral systems has been well studied, little is known about ET in the brain. The present study showed that brain immune cells, microglia, being different from peripheral macrophages, displayed non-cell...

article

Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

Shijun Wang, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, more

Journal of Neuroinflammation > 2016 > 13 > 1 > 1-19

Background Misfolded α-synuclein (α-Syn) aggregates participate in the pathogenesis of synucleinopathies, such as Parkinson’s disease. Whereas much is known about how the various domains within full-length α-Syn (FL-α-Syn) contribute to the formation of α-Syn aggregates and therefore to their neurotoxicity, little is known about whether the individual peptides that can be generated from α-syn, possibly...

article

A novel role of microglial NADPH oxidase in mediating extra‐synaptic function of norepinephrine in regulating brain immune homeostasis

Lulu Jiang, Shih‐Heng Chen, Chun‐Hsien Chu, Shi‐Jun Wang, more

Glia > 63 > 6 > 1057 - 1072

Although the peripheral anti‐inflammatory effect of norepinephrine (NE) is well documented, the mechanism by which this neurotransmitter functions as an anti‐inflammatory/neuroprotective agent in the central nervous system (CNS) is unclear. This article aimed to determine the anti‐inflammatory/neuroprotective effects and underlying mechanisms of NE in inflammation‐based dopaminergic neurotoxicity...

article

Interaction of DRD2TaqI , COMT , and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan

Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Yun-Hsuan Chang, more

Metabolic Brain Disease > 2015 > 30 > 3 > 755-765

It is hypothesized that dopaminergic genes—dopamine type-2 receptor ( DRD2 ), aldehyde dehydrogenase 2 ( ALDH2 ), and catechol-O-methyltransferase ( COMT )—are associated with bipolar disorder (BP) and anxiety disorder (AD). Bipolar II (BP-II) is reported to be highly comorbid with AD. We examined whether interactions among these three genes are susceptibility...

article

Microglial regulation of immunological and neuroprotective functions of astroglia

Shih‐Heng Chen, Esteban A. Oyarzabal, Yueh‐Feng Sung, Chun‐Hsien Chu, more

Glia > 63 > 1 > 118 - 131

Microglia and astroglia play critical roles in the development, function, and survival of neurons in the CNS. However, under inflammatory conditions the role of astrogliosis in the inflammatory process and its effects on neurons remains unclear. Here, we used several types of cell cultures treated with the bacterial inflammogen LPS to address these questions. We found that the presence of astroglia...

article

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

Qingshan Wang, Chun‐Hsien Chu, Esteban Oyarzabal, Lulu Jiang, more

Glia > 62 > 12 > 2034 - 2043

Activation of microglial NADPH oxidase (NOX2) plays a critical role in mediating neuroinflammation, which is closely linked with the pathogenesis of a variety of neurodegenerative diseases, including Parkinson's disease (PD). The inhibition of NOX2‐generated superoxide has become an effective strategy for developing disease‐modifying therapies for PD. However, the lack of specific and potent NOX2...

article

PGE₂ Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition

Chun-Hsien Chu, Shih-Heng Chen, Qingshan Wang, Robert Langenbach, more

Molecular Neurobiology > 2015 > 52 > 1 > 587-600

Regulatory mechanisms of the expression of interleukin-10 (IL-10) in brain inflammatory conditions remain elusive. To address this issue, we used multiple primary brain cell cultures to study the expression of IL-10 in lipopolysaccharide (LPS)-elicited inflammatory conditions. In neuron–glia cultures, LPS triggered well-orchestrated expression of various immune factors in the following order: tumor...

article

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia

Shiou-Lan Chen, Sheng-Yu Lee, Yun-Hsuan Chang, Shih-Heng Chen, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2014 > 51 > Complete > 99-104

Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several...

article

The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence

Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2013 > 43 > Complete > 134-139

Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. In addition, dopamine D2 receptor (DRD2) gene may also interact with the dopamine metabolizing genes and link to addiction. Therefore, we investigated the association between the...

article

Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese

Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2013 > 40 > Complete > 144-148

Several studies have hypothesized that genes involved in the dopamine system, including dopamine type-2 receptor (DRD2)-related TaqIA polymorphism and monoamine oxidase-A upstream variable number tandem repeat (uVNTR), may be associated with alcoholism. But their results were contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms...

article

Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders

Chiao-Ting Chang, Yun-Hsuan Chang, Jo Yung-Wei Wu, Sheng-Yu Lee, more

Psychiatry Research > 2012 > 200 > 2-3 > 246-251

Bipolar disorder (BP) patients with comorbid anxiety disorders (ADs) showed more severe clinical characteristics and psychosocial function impairment, worse response to treatment, and more substance use than those without AD. However, few studies focus on differences in neuropsychological function between BP-I and BP-II and patients with and without AD. Seventy-nine BP patients in their interepisode...

article

Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder

Sheng-Yu Lee, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2012 > 39 > 2 > 382-387

Bipolar disorder is a severe mental disorder with prominent genetic etiologic factors. Dopaminergic dysfunction has been implicated in the pathogenesis of bipolar disorder, which suggests that the dopamine D3 receptor gene (DRD3) is a strong candidate gene. The brain-derived neurotrophic factor (BDNF) gene has been implicated in the etiology of bipolar disorder. We examined the association between...

article

Interaction between *ALDH2**11 and DRD2/ANKK1 TaqI A1A1* genes may be associated with antisocial personality disorder not co‐morbid with alcoholism

Ru‐Band Lu, Jia‐Fu Lee, San‐Yuan Huang, Sheng‐Yu Lee, more

Addiction Biology > 17 > 5 > 865 - 874

Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene with neurotransmitters, such as dopamine, is suggested to be related to alcoholism...

article

Neuropsychological functions in bipolar disorders I and II with and without comorbid alcohol dependence

Yun-Hsuan Chang, Shiou-Lan Chen, Sheng-Yu Lee, Yu-Wen Hsu, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2012 > 37 > 2 > 211-216

Bipolar disorder (BP) is a mental disorder most likely to co-occur with substance dependence and abuse, especially alcohol dependence (ALD). Whether the effect of comorbid alcoholism is different between the BP-I and BP-II subtypes remains unclear. We aimed to identify the neuropsychological performance of BP patients with and without comorbid ALD in partial remission from depression or mania, and...

article

Executive functions in elderly men

Mu-En Liu, Yun-Hsuan Chang, Yan-Chiou Ku, Sheng-Yu Lee, more

AGE > 2012 > 34 > 1 > 59-66

The executive function deficit is greater in depressed patients with cardiovascular disease than in depressed patients without cardiovascular disease. Late-life depression is said to have a vascular etiology and would worsen the executive function. A cross-sectional design was used for this study. The study was done in outpatient clinics of Kaohsiung Veterans General Hospital and National Cheng Kung...

article

The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Shih-Heng Chen, more

Drug and Alcohol Dependence > 2012 > 120 > 1-3 > 220-224

Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence...

article

Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment

Shiou-Lan Chen, Sheng-Yu Lee, Pao-Luh Tao, Yun-Hsuan Chang, more

Journal of Neuroimmune Pharmacology > 2012 > 7 > 4 > 1025-1033

Recent studies show that proinflammatory cytokines might be related to the development of opioid dependence (physiological, psychological, or both). In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60–120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated...

article

Low-Dose Memantine Attenuated Morphine Addictive Behavior Through its Anti-Inflammation and Neurotrophic Effects in Rats

Shiou-Lan Chen, Pao-Luh Tao, Chun-Hsien Chu, Shih-Heng Chen, more

Journal of Neuroimmune Pharmacology > 2012 > 7 > 2 > 444-453

Opioid abuse and dependency are international problems. Studies have shown that neuronal inflammation and degeneration might be related to the development of opioid addiction. Thus, using neuroprotective agents might be beneficial for treating opioid addiction. Memantine, an Alzheimer’s disease medication, has neuroprotective effects in vitro and in vivo. In this study, we evaluated whether a low...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Chun-Hsien Chu

Physiological Concentration of Prostaglandin E₂ Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals

Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

A novel role of microglial NADPH oxidase in mediating extra‐synaptic function of norepinephrine in regulating brain immune homeostasis

Interaction of DRD2TaqI , COMT , and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan

Microglial regulation of immunological and neuroprotective functions of astroglia

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

PGE₂ Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia

The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence

Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese

Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders

Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder

Interaction between *ALDH2**11 and DRD2/ANKK1 TaqI A1A1* genes may be associated with antisocial personality disorder not co‐morbid with alcoholism

Neuropsychological functions in bipolar disorders I and II with and without comorbid alcohol dependence

Executive functions in elderly men

The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment

Low-Dose Memantine Attenuated Morphine Addictive Behavior Through its Anti-Inflammation and Neurotrophic Effects in Rats

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Chun-Hsien Chu

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options