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Enzyme-linked immunosorbent assay (ELISA) is a popular detection method which employs two antibodies. In this study, we presented a new method which used electromagnetically-driven microdevices to form an integrated microfluidic chip for automating ELISA-like dual aptamer assay. First, an electromagnetic micropump was designed and fabricated by using composite membranes. It was formed by mixing iron...
This study presents a new, pneumatically-driven micropump made of PDMS (polydimethylsiloxane) membranes for liquid delivery. Liquid samples can be transported by using a new mechanism generated by three oil-hydraulic chambers, which were first filled with liquid (mineral oil) and then deformed by compressed air such that an amplified deformation of the PDMS membranes can be generated for liquid transportation...
C-reactive protein (CRP) is commonly known as a clinical marker, which has been identified as an independent predictor for cardiovascular diseases such as heart attack and stroke. In this study, a new microfluidic system for automatic measurement of CRP is reported. The entire process including sample pre-treatment, incubation between target CRP and anti-CRP antibody, developing process and detection...
A new microfluidic reaction system capable of mixing, sample transportation and reaction is developed for synthesis of alloy magnetic nanoparticles. It allows for a rapid and cost-effective approach to accelerate the synthesis of the nanoparticles. The system integrated a micro-mixer/micro-pump, a micro-condenser, micro-valves, micro-heaters, and a micro temperature sensor to form a new microfluidic...
A new microfluidic reaction chip capable of mixing, transporting and reacting is developed for synthesis of gold nanoparticles with tunable sizes. It allows for a rapid and a cost-effective approach to accelerate the synthesis of gold nanoparticles. The microfluidic reaction chip was made of CNC machining and PDMS casting process to integrate a vortex-type micro-mixer and a micro-pump on a single...
In the study, we report a microfluidic-based dispenser fabricated by standard soft lithography of PDMS (polydimethylsiloxane) for sub-microliter range precise pipetting. The key feature of the microfluidic-based dispenser is the incorporation of a pressure-generating unit providing the driving force for precise and quick aqueous liquid sampling and pipetting. The microfluidic-based dispenser features...
A new microfluidic reaction system capable of mixing, transportation and reaction is developed for synthesis of nanoparticles. It allows for rapid, cost-effective, and environmentally friendly approach to accelerate the synthesis of the gold nanoparticles. The developed system integrated a micromixer, micropumps, microvalves, microheaters, and micro temperature sensors to form a microfluidic reactor...
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