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Downregulation of major histocompatibility complex class I chain‐related molecule A (MICA) and upregulation of human leukocyte antigen G (HLA‐G) on the tumor cells are important immune escape mechanisms for different epithelial tumors. In addition, upregulation of the soluble forms of the latter molecules in serum leads to peripheral T‐cell and natural killer (NK)‐cell tolerance. As for cervical cancer,...
AbstractThe human anti-(mouseIg) antibody (HAMA) response was measured in serum of 52 patients suspected of having ovarian carcinoma who had received an i.v. injection of either the murine monoclonal antibody (mAb) OV-TL 3 F(ab)2 (n = 28, 1mg) or the chimeric mouse/human mAb MOv18 (cMOv18; n =24, 3 mg). Serum samples were taken before injection and 23 and 614 weeks after administration. A double-antigen...
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