Search results for: Vincent Lai

Items from 1 to 20 out of 26 results

article

Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature

Cinzia Dello Russo, Tiziano Bandiera, Monica Monici, Leonardo Surdo, more

British Journal of Pharmacology > 179 > 11 > 2538 - 2557

As human spaceflight progresses with extended mission durations, the demand for effective and safe drugs will necessarily increase. To date, the accepted medications used during missions (for space motion sickness, sleep disturbances, allergies, pain, and sinus congestion) are administered under the assumption that they act as safely and efficaciously as on Earth. However, physiological changes have...

article

The addition of pretreatment plasma Epstein–Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification

Victor Ho‐Fun Lee, Dora Lai‐Wan Kwong, To‐Wai Leung, Cheuk‐Wai Choi, more

International Journal of Cancer > 144 > 7 > 1713 - 1722

The eighth edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage classification (TNM) for nasopharyngeal carcinoma (NPC) was launched. It remains unknown if incorporation of nonanatomic factors into the stage classification would better predict survival. We prospectively recruited 518 patients with nonmetastatic NPC treated with radical intensity‐modulated...

article

Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model

Vincent Lai, Victor Ho Fun Lee, Ka On Lam, Henry Chun Kin Sze, more

European Radiology > 2015 > 25 > 6 > 1708-1713

Purpose To determine the utility of stretched exponential diffusion model in characterisation of the water diffusion heterogeneity in different tumour stages of nasopharyngeal carcinoma (NPC). Materials and methods Fifty patients with newly diagnosed NPC were prospectively recruited. Diffusion-weighted MR imaging was performed using five b values (0–2,500 s/mm²). Respective stretched exponential...

article

Correlation between tissue metabolism and cellularity assessed by standardized uptake value and apparent diffusion coefficient in peritoneal metastasis

Xue Yu, Elaine Yuen Phin Lee, Vincent Lai, Queenie Chan

Journal of Magnetic Resonance Imaging > 40 > 1 > 99 - 105

PurposeTo evaluate the correlation between standardized uptake value (SUV) (tissue metabolism) and apparent diffusion coefficient (ADC) (water diffusivity) in peritoneal metastases. Materials and MethodsPatients with peritoneal dissemination detected on ¹⁸F‐fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG‐PET/CT) were prospectively recruited for MRI examinations...

article

A 130.7- $\hbox{mm}^{2}$ 2-Layer 32-Gb ReRAM Memory Device in 24-nm Technology

Tz-yi Liu, Tian Hong Yan, Roy Scheuerlein, Yingchang Chen, more

IEEE Journal of Solid-State Circuits > 2014 > 49 > 1 > 140 - 153

A 32-Gb ReRAM test chip has been developed in a 24-nm process, with a diode as the selection device and metal oxide as the switching element. The memory array is constructed with cross-point architecture to allow multiple memory layers stacked above the supporting circuitry and minimize the circuit area overhead. Die efficiency is further improved by sharing wordlines and bitlines between adjacent...

article

Nasopharyngeal carcinoma: comparison of diffusion and perfusion characteristics between different tumour stages using intravoxel incoherent motion MR imaging

Vincent Lai, Xiao Li, Victor Ho Fun Lee, Ka On Lam, more

European Radiology > 2014 > 24 > 1 > 176-183

Objective To explore intravoxel incoherent motion (IVIM) characteristics of nasopharyngeal carcinoma (NPC) and relationships with different tumour stages. Methods We prospectively recruited 80 patients with newly diagnosed undifferentiated NPC. Diffusion-weighted MR imaging was performed and IVIM parameters (D, pure diffusion; f, perfusion fraction; D*, pseudodiffusion coefficient) were calculated...

article

Transcultural and psychometric validation of the Dispositional Resilience Scale (DRS-15) in Chinese adult women

Janet Yuen-Ha Wong, Daniel Yee-Tak Fong, Anna Wai-Man Choi, Claudia Kor-Yee Chan, more

Quality of Life Research > 2014 > 23 > 9 > 2489-2494

Purpose The aim of this study was to report translation and transcultural adaptation of the 15-item Dispositional Resilience Scale in traditional Chinese (C-DRS-15) and evaluate its psychometric properties. Methods The DRS is a self-report instrument that measures psychological hardiness. We followed an international standard of cross-cultural translation and validation of patient-reported outcome...

chapter

A 130.7mm² 2-layer 32Gb ReRAM memory device in 24nm technology

Tz-Yi Liu, Tian Hong Yan, Roy Scheuerlein, Yingchang Chen, more

2013 IEEE International Solid-State Circuits Conference Digest of Technical Papers > 210 - 211

2013 IEEE International Solid-State Circuits Conference - (ISSCC)

ReRAM has been considered as one of the potential technologies for the next-generation nonvolatile memory, given its fast access speed, high reliability, and multi-level capability. Multiple-layered architectures have been used for several megabit test-chips and memory macros [1–3]. This paper presents a MeOx-based 32Gb ReRAM test chip developed in 24nm technology.

article

Intravoxel incoherent motion MR imaging: comparison of diffusion and perfusion characteristics between nasopharyngeal carcinoma and post-chemoradiation fibrosis

Vincent Lai, Xiao Li, Victor Ho Fun Lee, Ka On Lam, more

European Radiology > 2013 > 23 > 10 > 2793-2801

Objectives To compare the intravoxel incoherent motion (IVIM) diffusion and perfusion characteristics of nasopharyngeal carcinoma (NPC) and post-chemoradiation fibrosis to aid in their differentiation. Methods Fifty-three (64 %) patients with newly diagnosed NPC and 30 (36 %) patients with biopsy-proven post-chemoradiation fibrosis were recruited into tumour and fibrosis groups respectively. Diffusion-weighted...

article

Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage

Bingsheng Huang, Chun-Sing Wong, Brandon Whitcher, Dora Lai-Wan Kwong, more

European Radiology > 2013 > 23 > 6 > 1495-1502

Objectives To evaluate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for characterising nasopharyngeal carcinoma (NPC). Methods Forty-five newly diagnosed NPC patients were recruited. The initial enhancement rate (E _R), contrast transfer rate (k _ep), elimination rate (k _el), maximal enhancement (MaxEn) and initial area under the curve (iAUC) were calculated from semiquantitative...

article

Endovascular treatment paradigm of carotid blowout syndrome: Review of 8-years experience

Wing Suet Wan, Vincent Lai, Hin Yue Lau, Yiu Chung Wong, more

European Journal of Radiology > 2013 > 82 > 1 > 95-99

Endovascular treatment is effective in treating carotid blowout syndrome (CBS). We reviewed our experience in addressing CBS over eight years and presented an account of the treatment paradigm and management algorithm.All cases of CBS from 2003 to 2010 with endovascular treatment performed in our center were reviewed. 15 CBS in 14 patients were recruited. Based on our management algorithm, treatment...

article

Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders

Vincent Lai Ming Yip, Munir Pirmohamed

American Journal of Cardiovascular Drugs > 2013 > 13 > 3 > 151-162

Cardiovascular disease is a leading cause of death worldwide. Many pharmacologic therapies are available that aim to reduce the risk of cardiovascular disease but there is significant inter-individual variation in drug response, including both efficacy and toxicity. Pharmacogenetics aims to personalize medication choice and dosage to ensure that maximum clinical benefit is achieved whilst side effects...

article

Reply to Letter to the Editor “Why current evidence is against flow diverters for treatment of carotid blowout syndrome”

Vincent Lai, Wing Suet Wan

European Journal of Radiology > 2013 > 82 > 1 > 192

article

Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome

Cheuk Kei Kathy Wong, Vincent Lai, Yiu Chung Wong

European Journal of Radiology > 2012 > 81 > 5 > 1083-1087

To review and compare initial high resolution computed tomography (HRCT) findings in patients with metapneumovirus pneumonia and severe acute respiratory syndrome (SARS-Coronovirus).4 cases of metapneumovirus pneumonia (mean age of 52.3years) in an institutional outbreak (Castle Peak Hospital) in 2008 and 38 cases of SARS-coronovirus (mean age of 39.6years) admitted to Tuen Mun hospital during an...

article

Diagnostic power of various computed tomography signs in diagnosing acute appendicitis

Vincent Lai, Wan Chi Chan, Hin Yue Lau, Tsz Wai Yeung, more

Clinical Imaging > 2012 > 36 > 1 > 29-34

To review the diagnostic power of various computed tomography (CT) signs in acute appendicitis, in particular those initially classified as inconclusive.Retrospective review of 100 CT abdomen and pelvis studies with assessment of maximal luminal diameter, wall thickness and cross-sectional diameter of the appendix, periappendiceal inflammatory changes, and presence of appendicolith.All CT signs show...

article

Diagnostic accuracy of mediastinal width measurement on posteroanterior and anteroposterior chest radiographs in the depiction of acute nontraumatic thoracic aortic dissection

Vincent Lai, Wai Kan Tsang, Wan Chi Chan, Tsz Wai Yeung

Emergency Radiology > 2012 > 19 > 4 > 309-315

We aimed to explore the diagnostic accuracy of various mediastinal measurements in determining acute nontraumatic thoracic aortic dissection with respect to posteroanterior (PA) and anteroposterior (AP) chest radiographs, which had received little attention so far. We retrospectively reviewed 100 patients (50 PA and 50 AP chest radiographs) with confirmed acute thoracic aortic dissection and 120 patients...

article

Forward shifting of posterior dural sac during flexion cervical magnetic resonance imaging in Hirayama disease: An initial study on normal subjects compared to patients with Hirayama disease

Vincent Lai, Yiu Chung Wong, Wai Lun Poon, Ming Keung Yuen, more

European Journal of Radiology > 2011 > 80 > 3 > 724-728

Forward shifting of the posterior cervical dural sac is the most important sign in diagnosing Hirayama disease but can also be seen in normal subjects, causing potential diagnostic dilemma. We aim to explore the degree of forward displacement of posterior dural sac in normal subjects compared to that with Hirayama disease.50 healthy male teenagers and 3 patients with Hirayama disease were recruited...

article

Moyamoya syndrome associated with systemic lupus erythematosus: A case report and literature review

Tsz Wai Yeung, Vincent Lai, Hin Yue Lau, Yiu Chung Wong

European Journal of Radiology Extra > 2011 > 79 > 1 > e23-e26

Moyamoya disease is a chronic occlusive cerebrovascular disease affecting young patients. Its association with systemic lupus erythematosus (SLE) has not been well established though had been reported. Their similar acute neurological presentations can lead to diagnostic dilemma. We present a young Chinese female with known SLE initially presenting with unilateral moyamoya phenomenon, subsequently...

article

Focal brain herniation into giant arachnoid granulation: A rare occurrence

Wan Chi Chan, Vincent Lai, Yiu Chung Wong, Wai Lun Poon

European Journal of Radiology Extra > 2011 > 78 > 2 > e111-e113

Arachnoid granulations are normal anatomical structure that allows cerebrospinal fluid (CSF) drainage from subarachnoid space into venous system. They are asymptomatic but rarely can become symptomatic when they are large enough to cause sinus occlusion. We report a rare occurrence of focal brain herniation into a giant arachnoid granulation in a pediatric patient after sustaining severe head trauma...

article

Risk factors for mortality in cirrhotic patients with sepsis

Lee-Guan Lim, Xiang-Xuan Eunice Tan, Shu-Jeng Woo, Yock-Young Dan, more

Hepatology International > 2011 > 5 > 3 > 800-807

Background Patients with cirrhosis and sepsis had increased mortality. Aim Determine factors associated with increased in-hospital mortality in cirrhotic patients admitted for sepsis. Methods All cirrhotic patients admitted from 2004 to 2007 for sepsis were identified from hospital electronic database. Patients were included if they had liver cirrhosis and sepsis, defined as identified sources...

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INFONA - science communication portal

Search results for: Vincent Lai

Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature

The addition of pretreatment plasma Epstein–Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification

Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model

Correlation between tissue metabolism and cellularity assessed by standardized uptake value and apparent diffusion coefficient in peritoneal metastasis

A 130.7- $\hbox{mm}^{2}$ 2-Layer 32-Gb ReRAM Memory Device in 24-nm Technology

Nasopharyngeal carcinoma: comparison of diffusion and perfusion characteristics between different tumour stages using intravoxel incoherent motion MR imaging

Transcultural and psychometric validation of the Dispositional Resilience Scale (DRS-15) in Chinese adult women

A 130.7mm² 2-layer 32Gb ReRAM memory device in 24nm technology

Intravoxel incoherent motion MR imaging: comparison of diffusion and perfusion characteristics between nasopharyngeal carcinoma and post-chemoradiation fibrosis

Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage

Endovascular treatment paradigm of carotid blowout syndrome: Review of 8-years experience

Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders

Reply to Letter to the Editor “Why current evidence is against flow diverters for treatment of carotid blowout syndrome”

Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome

Diagnostic power of various computed tomography signs in diagnosing acute appendicitis

Diagnostic accuracy of mediastinal width measurement on posteroanterior and anteroposterior chest radiographs in the depiction of acute nontraumatic thoracic aortic dissection

Forward shifting of posterior dural sac during flexion cervical magnetic resonance imaging in Hirayama disease: An initial study on normal subjects compared to patients with Hirayama disease

Moyamoya syndrome associated with systemic lupus erythematosus: A case report and literature review

Focal brain herniation into giant arachnoid granulation: A rare occurrence

Risk factors for mortality in cirrhotic patients with sepsis

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