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DNA fragmentation is a hallmark of apoptosis that is induced by apoptotic stimuli in various cell types. Apoptotic signal pathways, which eventually cause DNA fragmentation, are largely mediated by the family of cysteinyl aspartate‐specific protease caspases. Caspases mediate apoptotic signal transduction by cleavage of apoptosis‐implicated proteins and the caspases themselves. In the process of caspase...
DNA fragmentation is a hallmark of apoptosis that occurs in a variety of cell types; however, it remains unclear whether caspase‐3 is required for its induction. To investigate this, we produced caspase‐3 knockout Chinese hamster ovary (CHO)‐K1 cells and examined the effects of gene knockout and treatment with caspase‐3 inhibitors. Okadaic acid (OA) is a potent inhibitor of the serine/threonine protein...
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