Search results for: Carlos Gallardo

Items from 1 to 20 out of 40 results

article

Study of the dielectric heating of graphite oxide and its effect on the microwave‐assisted synthesis of Nylon‐6/graphite oxide polymeric hybrid nanocomposites

Raquel Ledezma‐Rodríguez, Ernesto Hernández Hernández, Roberto Yáñez‐Macías, Zureima García Hernández, more

Journal of Applied Polymer Science > 139 > 5 > n/a - n/a

The present research focuses on the study of the microwave dielectric heating (DH) of graphite oxide (GrO) during the synthesis of Nylon‐6/GrO hybrid polymeric nanocomposites (HPNCs) employing different microwave input powers and two GrO morphologies. In this regard, we evaluated GrO powder (GrOP) with dimensions ranging from nanometers to microns and GrO films (GrOF) with millimeter lengths and micron...

article

Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage

Luis Francisco Calleja, Belem Yoval‐Sánchez, Luz Hernández‐Esquivel, Juan Carlos Gallardo‐Pérez, more

The FEBS Journal > 288 > 13 > 4064 - 4080

Under physiological conditions, cells produce low basal levels of reactive oxygen species (ROS); however, in pathologic conditions ROS production increases dramatically, generating high concentrations of toxic unsaturated aldehydes. Aldehyde dehydrogenases (ALDHs) are responsible for detoxification of these aldehydes protecting the cell. Due to the physiological relevance of these enzymes, it is important...

article

A Note on 3×3-valued Łukasiewicz Algebras with Negation

Carlos Gallardo, Alicia Ziliani

Bulletin of the Section of Logic > 2021 > 50 > 3 > 289-298

In 2004, C. Sanza, with the purpose of legitimizing the study of \(n\times m\)-valued Łukasiewicz algebras with negation (or \(\mathbf{NS}_{n\times m}\)-algebras) introduced \(3 \times 3\)-valued Łukasiewicz algebras with negation. Despite the various results obtained about \(\mathbf{NS}_{n\times m}\)-algebras, the structure of the free algebras for this variety has not been determined yet. She only...

article

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis

Barbara Iruretagoyena, Carmen P. Castañeda, Juan Undurraga, Rubén Nachar, more

Early Intervention in Psychiatry > 13 > 6 > 1382 - 1388

Aim Studies conducted in the United States have highlighted a higher prevalence of metabolic alterations (MA) in Latino population and Latino psychotic patients. Metabolic risk in psychosis is known to be present from initial stages of the disease. To better characterize this population, we explored the prevalence of MA and metabolic syndrome (MS) in early psychosis patients in a Latin American country...

article

Heart myxoma develops oncogenic and metastatic phenotype

Silvia Cecilia Pacheco-Velázquez, Juan Carlos Gallardo-Pérez, Daniel Díaz, Alhelí Adán-Ladrón de Guevara, more

Journal of Cancer Research and Clinical Oncology > 2019 > 145 > 5 > 1283-1295

Purpose Heart myxomas have been frequently considered as benign lesions associated with Carney’s complex. However, after surgical removal, myxomas re-emerge causing dysfunctional heart. Methods To identify whether cardiac myxomas may develop a metastatic phenotype as occurs in malignant cancers, a profile of several proteins involved in malignancy such as oncogenes (c-MYC, K-RAS and H-RAS), cancer-associated...

article

Mutant p53^R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

Ileana Hernández‐Reséndiz, Juan Carlos Gallardo‐Pérez, Ambar López‐Macay, Diana Xochiquetzal Robledo‐Cadena, more

Journal of Cellular Physiology > 234 > 5 > 5524 - 5536

Mutations in p53 are strongly associated with several highly malignant cancer phenotypes but its role in regulating energy metabolism has not been completely elucidated. The effect on glycolysis and oxidative phosphorylation (OxPhos) of mutant p53^R248Q overexpression in HeLa cells (HeLa‐M) was analyzed and compared with cells overexpressing wild‐type p53 (HeLa‐H) and nontransfected cells containing...

article

HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?

Juan C. Rodríguez‐Alba, Amayrani Abrego‐Peredo, Carlos Gallardo‐Hernández, Jocelyn Pérez‐Lara, more

BioEssays > 41 > 1 > n/a - n/a

Despite abundant evidence associating CD38 overexpression and CD4 T cell depletion in HIV infection, no causal relation has been investigated. To address this issue, a series of mechanisms are proposed, supported by evidence from different fields, by which CD38 overexpression can facilitate CD4 T cell depletion in HIV infection. According to this model, increased catalytic activity of CD38 may reduce...

article

Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria

Rafael Moreno-Sánchez, Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Citlali Vázquez, more

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2018 > 1859 > 10 > 1138-1150

To unveil what controls mitochondrial ROS detoxification, the NADPH supply and GSH/GSSG recycling for oxidative stress management were analyzed in cancer and non-cancer mitochondria. Therefore, proteomic and kinetomic analyses were carried out of the mitochondrial (i) NADPH producing and (ii) GSH/GSSG recycling enzymes associated to oxidative stress management. The protein contents of the eight enzymes...

article

Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core

Claudio Méndez‐Rojas, Gabriel Quiroz, Mario Faúndez, Carlos Gallardo‐Garrido, more

Archiv der Pharmazie > 351 > 5 > n/a - n/a

With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated a novel series of indole‐benzoxazinones (Family I) and benzoxazine‐arylpiperazine derivatives (Family II) for potential human acetylcholinesterase (hAChE) inhibitory properties. The most active compounds 7a and 7d demonstrated...

article

Control of the NADPH supply for oxidative stress handling in cancer cells

Rafael Moreno-Sánchez, Juan Carlos Gallardo-Pérez, Sara Rodríguez-Enríquez, Emma Saavedra, more

Free Radical Biology and Medicine > 2017 > 112 > C > 149-161

It has not been systematically analyzed whether the NADPH supply is a limiting factor for oxidative stress management in cancer cells. In the present work, it was determined in non-cancer and cancer cells the protein contents and kinetomics of (i) the cytosolic enzymes responsible for the NADPH production (i.e., Glc6PDH, 6PGDH, ME, IDH-1); and (ii) the two main enzymes responsible for NADPH/NADP⁺...

article

HPI/AMF inhibition halts the development of the aggressive phenotype of breast cancer stem cells

Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Alvaro Marín-Hernández, Rafael Moreno-Sánchez, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 10 > 1679-1690

Cancer stem cells are responsible for tumor recurrence and metastasis. A new highly reproducible procedure for human breast cancer MCF-7 stem cells (BCSC) isolation and selection was developed by using a combination of hypoxia/hypoglycemia plus taxol and adriamycin for 24h. The BCSC enriched fraction (i) expressed (2–15 times) the typical stemness protein markers CD44+, ALDH1A3 and Oct 3/4; (ii) increased...

chapter

Sliding-Mode control on DC-DC converters of a virtual power plant

Eduardo Avila, Marcelo Pozo, Oscar Camacho, Paulo Leica, more

2017 IEEE PES Innovative Smart Grid Technologies Conference - Latin America (ISGT Latin America) > 1 - 6

2017 IEEE PES Innovative Smart Grid Technologies Conference - Latin America (ISGT Latin America)

In this work, Sliding-Mode Control (SMC) is employed to control different DC-DC converters in a Photovoltaic-Wind-Battery based Virtual Power Plant (VPP). Firstly, the VPP scheme is detailed. Secondly, a DC-DC converter is employed on every Distributed Generator and Energy Storage System. Moreover, in order to integrate the output power of the DC-DC converters and for feeding a three-phase voltage...

chapter

Optimal location of sliding mode control and power system stabilizers in order to damp electromechanical oscillations using the residue

Carlos Gallardo, Marco Herrera, Merwin Ocana, Edison Guanochanga, more

2017 IEEE PES Innovative Smart Grid Technologies Conference - Latin America (ISGT Latin America) > 1 - 6

2017 IEEE PES Innovative Smart Grid Technologies Conference - Latin America (ISGT Latin America)

The purpose of this work is to find the optimal location of sliding mode control and power system stabilizer in order to damp electromechanical oscillations in the power system using the residue method. The proposed control is evaluated performing several simulations on a modified version of the 39-bus New England power grid. A modal analysis is performed at the test system in order to evaluate numerically...

article

Covalent grafting of polyacrylamide onto mesoporous MCM-41 silica via free radical polymerization

H. Iván Meléndez-Ortiz, Bertha Puente-Urbina, Griselda Castruita-de Leon, Carlos Gallardo-Vega, more

Journal of Porous Materials > 2017 > 24 > 6 > 1527-1533

MCM-41 mesoporous silicas were covalently modified with polyacrylamide (PAAm) by a novel grafting strategy. The effect of various parameters such as monomer concentration, reaction time, and temperature on the content of PAAm onto MCM-41 silicas were studied. Modified silicas were characterized by X-ray diffraction (XRD), infrared spectroscopy, FT-IR, thermogravimetric analysis, nitrogen adsorption–desorption...

article

Hypoglycemia Enhances Epithelial‐Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids

Álvaro Marín‐Hernández, Juan Carlos Gallardo‐Pérez, Ileana Hernández‐Reséndiz, Isis Del Mazo‐Monsalvo, more

Journal of Cellular Physiology > 232 > 6 > 1346 - 1359

The accelerated growth of solid tumors leads to episodes of both hypoxia and hypoglycemia (HH) affecting their intermediary metabolism, signal transduction, and transcriptional activity. A previous study showed that normoxia (20% O₂) plus 24 h hypoglycemia (2.5 mM glucose) increased glycolytic flux whereas oxidative phosphorylation (OxPhos) was unchanged versus normoglycemia in HeLa cells. However,...

chapter

Active power control of a Virtual Power Plant

Xavier Dominguez, Marcelo Pozo, Carlos Gallardo, Leonardo Ortega

2016 IEEE Ecuador Technical Chapters Meeting (ETCM) > 1 > 1 - 6

2016 IEEE Ecuador Technical Chapters Meeting (ETCM)

The present work develops the entire control system to achieve the active power regulation in a detailed model of a small-scale Virtual Power Plant (VPP). Firstly, the proposed VPP topology is exposed. A DC bus has been used for the integration of the different distributed generators and the storage system. Different DC-DC power converters schemes have been employed to fulfill this goal. Later, by...

article

The nutritional status of Methanosarcina acetivorans regulates glycogen metabolism and gluconeogenesis and glycolysis fluxes

Michel Geovanni Santiago‐Martínez, Rusely Encalada, Elizabeth Lira‐Silva, Erika Pineda, more

The FEBS Journal > 283 > 10 > 1979 - 1999

Gluconeogenesis is an essential pathway in methanogens because they are unable to use exogenous hexoses as carbon source for cell growth. With the aim of understanding the regulatory mechanisms of central carbon metabolism in Methanosarcina acetivorans, the present study investigated gene expression, the activities and metabolic regulation of key enzymes, metabolite contents and fluxes of gluconeogenesis,...

article

Testing of model-driven development applications

Beatriz Marín, Carlos Gallardo, Diego Quiroga, Giovanni Giachetti, more

Software Quality Journal > 2017 > 25 > 2 > 407-435

Human resource management practices are key for the success of software development projects. Practices that promote knowledge sharing and organizational learning are positively related to development–effort curves, and thus software companies are looking for different alternatives oriented to promoting these practices. The model-driven development (MDD) paradigm is positioned as one of the best alternatives...

article

Understanding the cancer cell phenotype beyond the limitations of current omics analyses

Rafael Moreno‐Sánchez, Emma Saavedra, Juan Carlos Gallardo‐Pérez, Franklin D. Rumjanek, more

The FEBS Journal > 283 > 1 > 54 - 73

Efforts to understand the mechanistic principles driving cancer metabolism and proliferation have been lately governed by genomic, transcriptomic and proteomic studies. This paper analyzes the caveats of these approaches. As molecular biology's central dogma proposes a unidirectional flux of information from genes to mRNA to proteins, it has frequently been assumed that monitoring the changes in the...

article

Dual regulation of energy metabolism by p53 in human cervix and breast cancer cells

Ileana Hernández-Reséndiz, Alejandra Román-Rosales, Enríque García-Villa, Ambar López-Macay, more

BBA - Molecular Cell Research > 2015 > 1853 > 12 > 3266-3278

The role of p53 as modulator of OxPhos and glycolysis was analyzed in HeLa-L (cells containing negligible p53 protein levels) and HeLa-H (p53-overexpressing) human cervix cancer cells under normoxia and hypoxia. In normoxia, functional p53, mitochondrial enzyme contents, mitochondrial electrical potential (ΔΨ_m) and OxPhos flux increased in HeLa-H vs. HeLa-L cells; whereas their glycolytic enzyme contents...

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GLYCOLYSIS (5)
OXIDATIVE PHOSPHORYLATION (5)
GENERATORS (3)
OXIDATIVE STRESS (3)
ANTI-MITOCHONDRIAL THERAPY (2)
BREAST CANCER (2)
CANCER CELLS (2)
DISTRIBUTED GENERATION (2)
ENERGY METABOLISM (2)
HEXOKINASE (2)
HYPOXIA (2)
KINETIC MODELING (2)
METABOLIC CONTROL ANALYSIS (2)
METASTATIC PHENOTYPE (2)
MITOCHONDRIA (2)
OPTICAL PROPERTIES (2)
REACTIVE OXYGEN SPECIES (2)
SLIDING MODE CONTROL (2)
TUMOR CELLS (2)
VIRTUAL POWER PLANT (2)
WIND TURBINES (2)
4‐HNE (1)
ABSTRACT TEST CASE (1)
ACTIVE POWER CONTROL (1)
AFM (1)
ALDHS (1)
ALTERNATIVE OXIDASE (1)
ALZHEIMER'S DISEASE (1)
ANAEROBIC METABOLISM (1)
ATOMIC FORCE MICROSCOPY (AFM) (1)
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BENZOXAZINONES (1)
BIOMARKER PATTERNS (1)
BIOMASS PRODUCTION (1)
BIOSORPTION (1)
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BROMOPYRUVATE (1)
CADMIUM POLLUTION (1)
CALCIUM (1)
CANCER METABOLISM (1)
CANCER SYSTEMS BIOLOGY (1)
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CASIOPEINA (1)
CD38 (1)
CD4‐POSITIVE T LYMPHOCYTES (1)
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CHILE (1)
CHORUS GIGANTEUS (1)
CHROMIUM ACCUMULATION (1)
CISPLATIN (1)
COMBINATION THERAPY (1)
COMBINED THERAPY (1)
COMPOSITES (1)
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CONTROL AND REGULATION ANALYSIS (1)
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DAMPING (1)
DC-DC POWER CONVERTERS (1)
EARLY PSYCHOSIS (1)
EFM (1)
EIGENVALUES AND EIGENFUNCTIONS (1)
ENERGY MANAGEMENT (1)
ENERGY MANAGEMENT SYSTEM (1)
ENZYME INHIBITION (1)
EPITHELIAL–MESENCHYMAL TRANSITION (1)
ESTROGEN RECEPTORS (1)
ESTROGENS (1)
EXTERNAL NADH DEHYDROGENASE (1)
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FLUX-CONTROL COEFFICIENT (1)
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GLUTATHIONE PEROXIDASE-1 (1)
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GRAPHENE (1)
HEART MITOCHONDRIA (1)
HEART STROKE AND GENDER (1)
HEARTH MYXOMA (1)
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HEXOSE-PHOSPHATE ISOMERASE (1)
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INFONA - science communication portal

Search results for: Carlos Gallardo

Study of the dielectric heating of graphite oxide and its effect on the microwave‐assisted synthesis of Nylon‐6/graphite oxide polymeric hybrid nanocomposites

Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage

A Note on 3×3-valued Łukasiewicz Algebras with Negation

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis

Heart myxoma develops oncogenic and metastatic phenotype

Mutant p53^R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?

Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria

Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core

Control of the NADPH supply for oxidative stress handling in cancer cells

HPI/AMF inhibition halts the development of the aggressive phenotype of breast cancer stem cells

Sliding-Mode control on DC-DC converters of a virtual power plant

Optimal location of sliding mode control and power system stabilizers in order to damp electromechanical oscillations using the residue

Covalent grafting of polyacrylamide onto mesoporous MCM-41 silica via free radical polymerization

Hypoglycemia Enhances Epithelial‐Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids

Active power control of a Virtual Power Plant

The nutritional status of Methanosarcina acetivorans regulates glycogen metabolism and gluconeogenesis and glycolysis fluxes

Testing of model-driven development applications

Understanding the cancer cell phenotype beyond the limitations of current omics analyses

Dual regulation of energy metabolism by p53 in human cervix and breast cancer cells

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