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Zn2+‐induced β‐amyloid protein (Aβ) aggregation and microglia activation are the predominant contributors in Alzheimer's disease (AD). Regulating intracephalic excessive Zn2+ is a promising therapeutic strategy for AD treatment. However, only inhibition of Zn2+ is hardly to repair continuous damages caused by activated microglia. Herein, an intelligent resveratrol‐loaded supramolecular vesicles (RES‐loaded...
Macrophages as the main cause of cancer immunosuppression, how to effectively induce macrophage M1 polarization remain the major challenge in lung cancer therapy. Herein, inspired by endogenous reactions, a strategy is proposed to coactivate macrophage M1 polarization by reactive oxygen species (ROS) and nitric oxide (NO) with self‐autocatalytic cascade reaction. To enhance the generation of NO and...
Inherited bacterial resistance and biofilm‐induced local immune inactivation are important factors in the failure of antibiotics to fight against bacterial infections. Herein, antibiotic‐loaded mesoporous nanozymes (HA@MRuO2‐Cip/GOx) are fabricated for overcoming bacterial resistance, and activating the local immunosuppression in biofilm microenvironment (BME). HA@MRuO2‐Cip/GOx are prepared by physical...
We experimentally demonstrate a simplified scheme of stimulated Brillouin scattering (SBS) pulse compression of broadband microwave signal based on differential detection. The simplified pulse compression without subtraction is implemented by use of a parallel delay line without SBS gain and a balanced photodetector. The experimental results shows a higher performance of pulse compression by eliminating...
BACKGROUND: In animal diets, methionine (Met) is considered to be the first limiting amino acid, and the activity of synthetic Met is typically added either as DL‐methionine (DLM) or as DL‐2‐hydroxy‐4‐methylthiobutanoic acid (HMTBA). It has been demonstrated that HMTBA exhibits a higher antioxidant capability in vitro as compared to DLM. However, the difference in antioxidant capability between DLM...
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