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Satellite glial cells (SGCs) are supporting cells enveloping and isolating soma of neurons in sensory ganglia such as dorsal root ganglion (DRG) in the peripheral nervous system. Recent studies have shown that they are involved in intercellular communication between neuronal somata within ganglia in chronic pain and inflammatory conditions. One hypothesis proposed for this communication is via release...
The ability to detect noxious stimuli and evoke a defensive response is made possible by specialized peripheral sensory neurons called nociceptors that respond to stimuli such as extreme temperature, pressure and injury. A number of experimental studies have been done on nociceptors at various range of temperatures in order to understand the underlying biophysical mechanisms. Simple models for describing...
The urinary bladder afferent neurons called the dorsal root ganglion (DRG) neurons carry information on diverse modalities such as stretch, pressure and nociception to the spinal cord. This information is carried in the form of electrical activity called action potentials (AP). The bladder small diameter DRG neurons that are considered to be putative nociceptors express several ion channels and active...
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