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A wirelessly-operated implantable site specific drug delivery micropump with on-demand control of dosing for chronic infusion applications in small laboratory animals is presented. The system includes an electrolysis-based actuator, refillable drug reservoir, wireless powering, and a check valve. Micropumps were fabricated, assembled, and tested in simulated in vivo conditions. As expected, power...
Rodents are the most widely used animal model in the study of human disease and drug administration technologies suitable for use in rodents are therefore critically important in the development of new treatments. Implantable drug delivery devices provide site specific and controlled drug administration while eliminating frequent handling, tethers, and stress induction associated with other drug delivery...
The clinico-pathological features of 17 patients displaying a myopathy with lobulated (trabeculated) fibers are reported. All these patients had a limb girdle phenotype and at least 20% of lobulated fibers in their muscle biopsies. There were ten females and seven males. The onset of symptoms ranged from 2 to 55 years (mean 24). The average age at the time of muscle biopsy was 39 (range 3-63). Interestingly,...
A survey of limb girdle muscular dystrophy has been carried out in 1995-1996 in the Basque province of Guipuzcoa (702@000 inhabitants). Patients were ascertained through medical records kept by local hospitals and through information held by patients support groups. The diagnostic criteria were those agreed tt the ENMC workshop held in Naarden in 1995. All patients were re-examined by two neurologists...
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