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In radiation therapy (RT), brachytherapy-inert source spacers are commonly used in clinical practice to achieve high spatial accuracy. These implanted devices are critical technical components of precise radiation delivery but provide no direct therapeutic benefits.Here we have fabricated implantable nanoplatforms or chemoradiation therapy (INCeRT) spacers loaded with silica nanoparticles (SNPs) conjugated...
New implantable smart nanoparticle (NP) coated brachytherapy spacers have recently been developed which allows controlled, long-term release of chemotherapeutic drugs into tumors. However, kinetics of NP (drug) diffusion over time is still poorly understood, and new methods for controlling and optimizing this release are needed. In this work, we developed and validated a novel broad-field transmission...
Systemic chemotherapy is often used with radiation therapy in the management of prostate cancer, but leads to severe systemic toxicities. We have introduced a new modality of loco-regional chemoradiation therapy termed in-situ image guided radiation therapy (BIS-IGRT) that offers the potential to deliver planned, localized and sustained delivery of chemotherapy agent, without systemic toxicities,...
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