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The medium spiny neurons of the ventral medial and dorsolateral striatum play different roles in the basal ganglia. Certain differences stem from distinct NMDA receptor behaviors. To demonstrate these differences NMDA receptor time constants were adapted in our striatal medium spiny neuron model. The respective parameter values were set at published ventromedial and derived dorsolateral striatal values...
The striatum is believed to be the main input station of the basal ganglia. No biophysical network model existed in NEURON of a dorsal lateral striatal medium spiny neuron (MSN) that included NMDA and AMPA receptors. A model of the striatum that includes these receptors simulating in-vivo electrophysiological behavior is presented. A single compartment MSN (scMSN) model was created by enhancing an...