Search results for: An Liping
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Experimental Cell Research > 2016 > 343 > 2 > 208-217
TNF-α is known to induce osteoblasts apoptosis, whereas mechanical stimulation has been shown to enhance osteoblast survival. In the present study, we found that mechanical stimulation in the form of fluid shear stress (FSS) suppresses TNF-α induced apoptosis in MC3T3-E1 cells. Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family that has...
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Biochemical and Biophysical Research Communications > 2015 > 466 > 1 > 117-123
Fluid shear stress (FSS) is a potent mechanical stimulus and prevents cells from TNF-a-induced apoptosis. Recently, Extracellular-signal-regulated kinase 5 (ERK5) has been found to be involved in regulation of cell survival. However, little is known about the role of ERK5 signaling pathway in FSS-mediated anti-apoptotic effects in osteoblast. In this study, we show that FSS blocks TNF-a-induced apoptosis...
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In this study, in vitro cultured islet RINm5f cells were used to observe effects of exenatide on the apoptosis induced by palmitate and explore its mechanism. MTT, AO/EB bi-label assay, flow cytometry and laser confocal microscope were applied for the observation of the cell proliferation, survival rate, apoptosis rate and morphological change. The results confirmed that the survival rate of cultured...
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Domain 5 (D5) of high molecular weight kininogen represent significant anti-invasion properties towards tumor cells, and His-Gly-Lys (HGK) in D5 is the core motif for inhibition of invasion. In an attempt to identify the core amino acid of HGK in the process of tumor invasion, PCR-mediated site-directed mutagenesis technology was use to generate 3 mutant constructs, pGEX-4T-1/D5 (H485A), pGEX-4T-1/D5...
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Objective: To explore the effects of decreasing blood glucose of extracts of corn and the pupa to diabetic rats induced by STZ. Method: The mixture of corn and the pupa is extracted by water lifting reduction. ICR rats were intraperitoneally injected of STZ 40 mg/Kg, animal model of diabetes was prepared; to observe fasting blood glucose levels (FBG) of mice with glucose oxidase; to observe the serum...
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GHGKHKNK octapeptide has tumoricidal potential mainly due to the amino acid residues of His-Gly-Lys motif inhibits the clone formation, adhesion and invasion of tumor cells. However, its clinical application is limited by its short half-life time in vivo. We used human serum albumin (HSA) fusion technology to fuse GHGKHKNK octapeptide and HSA to prolong half-life time of GHGKHKNK octapeptide and increase...
