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In previous studies, increasing number of teeth predicted better survival and the acute needs for dental treatment predicted mortality. We sought to investigate whether restored dentitions by various removable dental prostheses impact cardiovascular (CVD) longevity.Kuopio Oral Health and Heart study was initiated as a cross-sectional investigation with 256 subjects with diagnosed coronary artery disease...
Model-driven engineering (MDE) introduces additional challenges for managing evolution. For example, a metamodel change may affect instance models. Existing tool supported approaches for updating models in response to a metamodel change assume extra effort from metamodel developers. When no existing approach is applicable, metamodel users must update their models manually, an error prone and tedious...
Model management is the discipline of managing artefacts used in Model-Driven Engineering (MDE). A model management framework defines and implements the operations (such as transformation or code generation) required to manipulate MDE artefacts. Modern approaches to model management generally implement these operations via domain-specific languages (DSLs). This paper presents and compares the principles...
The Eclipse graphical modeling framework (GMF) provides substantial infrastructure and tooling for developing diagram-based editors for modelling languages atop the Eclipse platform. It is widely accepted that implementing a visual editor using the built-in GMF facilities is a particularly complex and error-prone task and requires a steep learning curve. We present an approach that raises the level...
A model management workflow typically consists of a number of interdependent model-management tasks such as model validation, transformation, merging, comparison and text generation. As such workflows are becoming more and more complex, errors in individual tasks are likely to be propagated to subsequent tasks and eventually compromise the operation of the entire workflow. Therefore, building confidence...
CdG is a potent inhibitor of herpes simplex virus (HSV), hepatitis-B virus (HBV), and cytomegalo virus (CMV) DNA replication. In HSV-infected cells it is activated (phosphorylated) by the HSV-encoded thymidine kinase. Previously, we have shown that both enantiomers of CdG are phosphorylated in human cells. Because HBV and CMV do not express nucleoside kinases, it was of interest to identify the...
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