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Drug safety research is frequently faced with the challenge of the selection of appropriate vehicles for use in in vivo non-clinical safety assessment studies. Reported here are the results of blend Labrasol®, Labrafil® and Transcutol® , [L/L/T, (4/4/2, v/v/v)], excipients used as bioavailability enhancer and solubilizer for poorly water-soluble compounds and tested daily for 4weeks by oral route...
Currently, modifications of lymph node (LN) size in mice are evaluated using invasive characterization of LN cell- count and weight after dissection. This work evaluated the use of 24-MHz ultrasound to discriminate modifications of LN size in vivo. The sub-iliac LN are very small organs (long axis approximately two millimeters for adult C57BL/6 mice) situated about one millimeter beneath the skin...
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