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Clostridium perfringens type A, an anaerobic pathogen is the most potent cause of soft tissue infections like gas gangrene and enteric diseases like food poisoning and enteritis. The disease manifestations are mediated via two important exotoxins, viz. myonecrotic alpha toxin (αC) and enterotoxin (CPE). In the present study, we synthesized a bivalent chimeric protein r-Cpae comprising C-terminal binding...
Anthrax, a fatal zoonotic disease caused by spore forming bacteria Bacillus anthracis is predominantly witnessed among herbivorous animals that are highly susceptible to the pathogen. Typically B. anthracis spores existing in soil, initiate the infection during grazing and animal to animal spread has been rarely reported. A suspected outbreak of anthrax was observed among cattle in Gundlupet taluk...
Clostridium perfringens and Staphylococcus aureus are the two important bacteria frequently associated with majority of the soft tissue infections. The severity and progression of the diseases caused by these pathogens are attributed primarily to the alpha toxins they produce. Previously, we synthesized a non-toxic chimeric molecule r-αCS encompassing the binding domains of C. perfringens and S. aureus...
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