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The immunosuppressive effects of ultraviolet (UV) radiation on the functionality of the skin immune system (SIS) have been known for several years. This suppression of cutaneous immune responses by UV-radiation may derive from direct effects on immuno-competent cells within the epidermis or the dermis, or from indirect effects mediated through the action of UV-radiation on keratinocytes (e.g. via...
Cultured human skin fibroblasts from control persons and from patients with the generalized and late-onset forms of Pompe's disease were labelled with radioactive leucine and the incorporation of radioactivity into acid α-glucosidase and cathepsin D was analysed by immunoprecipitation, gel electrophoresis and fluorography. When the labelling was carried out for 6-12 h in the presence of NH 4 ...
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