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Emigration of human epidermal Langerhans cells (LC), following exposure to contact allergens, is critical in the initiation of contact hypersensitivity (CHS) reactions in the skin. It was recently suggested that certain cytokines (e.g. IL-1β, TNF-a) and matrix metalloproteinases (MMPs) are important for the migration of murine LC and human blood derived dendritic cells. Particularly MMPs due to...
Introduction: Epidermal Langerhans cells (LC) play a critical role in the initiation of contact hypersensitivity (CHS) reactions in the skin. Little is known about the mechanisms of emigration of human LC following exposure to contact allergens. It was recently suggested that matrix metalloproteinases (MMPs) are important for the migration of murine LC and human dendritic cells, probably due to...
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