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cDNAs encoding three phospholipase A 2 (PLA 2 ) isoforms in Naja naja sputatrix were cloned and characterized. One of them encoded an acidic PLA 2 (APLA) while the others encoded neutral PLA 2 (NPLA-1 and NPLA-2). The specific characteristics of APLA and NPLA were attributed to mutations at nt139 and nt328 from G to C and G to A, respectively, resulting in amino acid...
Crude venoms from Daboia russelli siamensis, Vipera russelli siamensis, V. r. russelli, and V. r. pulchella on double immunodiffusion gave positive reactions with equine antivenin or with rabbit antisera to daboiatoxin (DbTx), a major lethal principle of D. r. siamensis venom. The precipitin bands cross-reacted each other, indicating similar antigenic determinants present in those venoms. Sodium...
Daboiatoxin (DbTx), a phospholipase A 2 neurotoxin purified from Daboia russelii siamensis venom and radioiodinated to high specific activity (500-700 Ci/mmole), bound specifically with high affinity to synaptosomes from Wistar rat, snake (Python reticulatus), and little civet cat (Viverricula indica). While rat brain synaptosomes contained two different binding sites of high and low affinities...
Maung-Maung-Thwin, P. Gopalakrishnakone, R. Yuen and C. H. Tan. Synaptosomal binding of 125 I-labelled daboiatoxin, a new PLA 2 neurotoxin from the venom of Daboia russelli siamensis. Toxicon 34, 183-199, 1996.--Daboiatoxin (DbTx), the PLA 2 neurotoxin from Daboia russelli siamensis venom, was shown to bind specifically and saturably to rat cerebrocortical synaptosomes...
Daboiatoxin (DbTx) is a neurotoxic phospholipase A 2 isolated from the venom of Burmese Russell's viper (Daboia russelli siamensis). Using biologically active 125 I-DbTx, specific binding sites of high affinity were detected on rat cerebrocortical synaptosomes and synaptic membrane fragments. Scatchard analyses of biphasic binding plateaus gave K dl : 5 nM...
Rhodostoxin is the major hemorrhagic protease of Calloselasma rhodostoma (Malayan pit viper) venom. It has a mol. wt of 30,000 with 15% carbohydrate. The amino acid sequence of rhodostoxin was determined by automated Edman microsequencing of peptides derived from digest with endoproteinase Lys-C, and the location of four disulfide bridges was also elucidated. The sequence is homologous to that...
Neurotoxins are the most toxic components present in Elapidae venoms. Several isoforms of neurotoxin have been isolated from cobra venoms. In Naja naja sputatrix, three isoforms of neurotoxin have been isolated by gel filtration and high-performance liquid chromatographic procedures. We then isolated cDNA clones by RT-PCR. Further characterization of these clones by DNA sequencing led us to confirm...
Multiple isoforms of phospholipase A 2 have been identified in Elapidae venoms. Three phospholipase A 2 isozymes were isolated from Naja naja sputatrix venom by gel filtration and high-performance liquid chromatographic procedures. The primary structure of the phospholipase A 2 enzyme(s) was determined by cDNA cloning and sequencing. The nucleotide sequence of these clones...
A highly potent toxin isolated from Lophozozymus pictor (LPTX) was shown to be cytotoxic to HeLa and Rat 1 cells. The toxin also promoted the release of K + from HeLa cells. LPTX-treated cells showed morphological changes (increased granulation, cell rounding, vacuolization and swelling) which resulted in cell lysis. Cell damage was also monitored by trypan blue exclusion. Prior to observable...
Snakebite is a public health problem in most tropical countries. Cobra envenomation causes significant mortality and morbidity, causing a variety of symptoms, the most important being potentially fatal neurotoxic and cardiotoxic effects and local tissue damage which can be crippling. One of the common and highly poisonous cobras around this region is the Malayan spitting cobra (Naja naja sputatrix)...
Magnificalysin I and II (HMg I and II) and equinatoxin II (EqTx II) are cytolytic toxins extracted from sea anemones Heteractis magnifica and Actinia equina, respectively. They induced haemolysis in rat red blood cells and inhibited gamma amino butyric acid (GABA) and choline uptake into rat brain synaptosomes. These effects were concentration dependent. The inhibition of GABA and choline uptake...
Purified Lophozozymus pictor toxin (LPTX) shares many properties similar to palytoxin (PTX). LPTX and palytoxin isolated from Palythoa caribaeorum (C-PTX) have similar mol. wts of approx. 2680 on ionspray mass spectrometry (MS). In addition, antibodies against PTX could recognize and bind LPTX. Mixed mode high-performance liquid chromatography (HPLC) of LPTX, C-PTX and H-PTX (isolated fromPalythoa...
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