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Neurotoxins are the most toxic components present in Elapidae venoms. Several isoforms of neurotoxin have been isolated from cobra venoms. In Naja naja sputatrix, three isoforms of neurotoxin have been isolated by gel filtration and high-performance liquid chromatographic procedures. We then isolated cDNA clones by RT-PCR. Further characterization of these clones by DNA sequencing led us to confirm...
Snakebite is a public health problem in most tropical countries. Cobra envenomation causes significant mortality and morbidity, causing a variety of symptoms, the most important being potentially fatal neurotoxic and cardiotoxic effects and local tissue damage which can be crippling. One of the common and highly poisonous cobras around this region is the Malayan spitting cobra (Naja naja sputatrix)...