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In humans, three distinct but closely related classes of receptors that bind the Fc portion of IgG (FcγRI, II, and III) have been identified. FcγRI can bind monomeric IgG with high affinity and has a unique third extracellular domain (EC3). Three very similar genes have been characterized for FcγRI (A, B, C). Although the sequences are remarkably similar, a number of coding-region differences discriminate...
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