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Unraveling the mechanisms underlying autoimmune disease remains a difficult challenge. Recent lessons learned from the study of AIRE (autoimmune regulator), the gene responsible for the rare monogenic human syndrome APS-1, highlight the power of genetics to reveal disease pathogenesis. With the discovery of AIRE, central tolerance has re-emerged as a crucial check against autoimmunity. Aire-mediated...
TheDrosophila boulegene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by theDAZ(Deleted in Azoospermia) andDAZL(DAZ-like) genes. Mutation ofbouleblocks both meiotic divisions. Differentiation nonetheless continues, resulting in tetraploid spermatids that fail to mature into sperm. We have found that Boule...
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