Search results for: Mathias Gelderblom

Items from 1 to 18 out of 18 results

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Large‐Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes

Mirja Thomsen, Katrin Marth, Sebastian Loens, Judith Everding, more

Background Pathogenic variants in several genes have been linked to genetic forms of isolated or combined dystonia. The phenotypic and genetic spectrum and the frequency of pathogenic variants in these genes have not yet been fully elucidated, neither in patients with dystonia nor with other, sometimes co‐occurring movement disorders such as Parkinson's disease (PD). Objectives To screen >2000...

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Cerebellar Modulation of Sensorimotor Associative Plasticity Is Impaired in Cervical Dystonia

Kai Grimm, Lisa Prilop, Gerhard Schön, Mathias Gelderblom, more

Movement Disorders > 38 > 11 > 2084 - 2093

Background In recent years, cervical dystonia (CD) has been recognized as a network disorder that involves not only the basal ganglia but other brain regions, such as the primary motor and somatosensory cortex, brainstem, and cerebellum. So far, the role of the cerebellum in the pathophysiology of dystonia is only poorly understood. Objective The objective of this study was to investigate the role...

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A Multi‐center Genome‐wide Association Study of Cervical Dystonia

Yan V. Sun, Chengchen Li, Qin Hui, Yunfeng Huang, more

Movement Disorders > 36 > 12 > 2795 - 2801

Background Several monogenic causes for isolated dystonia have been identified, but they collectively account for only a small proportion of cases. Two genome‐wide association studies have reported a few potential dystonia risk loci; but conclusions have been limited by small sample sizes, partial coverage of genetic variants, or poor reproducibility. Objective To identify robust genetic variants...

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Nerve trauma of the lower extremity: evaluation of 60,422 leg injured patients from the TraumaRegister DGU® between 2002 and 2015

Torge Huckhagel, Jakob Nüchtern, Jan Regelsberger, Mathias Gelderblom, more

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine > 2018 > 26 > 1 > 1-8

Background Nerve lesions are well known reasons for reduced functional capacity and diminished quality of life. By now only a few epidemiological studies focus on lower extremity trauma related nerve injuries. This study reveals frequency and characteristics of nerve damages in patients with leg trauma in the European context. Methods Sixty thousand four hundred twenty-two significant limb trauma...

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Muscle action potential scans and ultrasound imaging in neurofibromatosis type 2

Said Farschtschi, Mathias Gelderblom, Sabriena Buschbaum, Hugh Bostock, more

Muscle & Nerve > 55 > 3 > 350 - 358

Introduction The neuropathy in patients with neurofibromatosis type 2 (NF2) is difficult to quantify and follow up. In this study we compared 3 methods that may help assess motor axon pathology in NF2 patients. Methods Nerve conduction studies in median nerves were supplemented by deriving motor unit number estimates (MUNEs) from compound muscle action potential (CMAP) scans and by high‐resolution...

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Dendritic cells in brain diseases

Peter Ludewig, Mattia Gallizioli, Xabier Urra, Sarah Behr, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2016 > 1862 > 3 > 352-367

Dendritic cells (DCs) are professional antigen presenting cells that constantly survey the environment acting as sentinels of the immune system, including in the CNS. DCs are strategically located near the cerebrospinal fluid, but they can potentially migrate to draining cervical lymph nodes either triggering immunogenic T cell responses or displaying tolerogenic functions. Under physiological conditions,...

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Danger signals in stroke

Mathias Gelderblom, Christopher G. Sobey, Christoph Kleinschnitz, Tim Magnus

Ageing Research Reviews > 2015 > 24 > Part A > 77-82

Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a...

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PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Pei Ching (Regine) Low, Silvia Manzanero, Vinod K. Narayana, Tam H. Nguyen, more

Cytokine > 2014 > 70 > 1 > 56

Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumor necrosis factor alpha (TNF), exacerbating tissue damage and worsening the outcomes for stroke patients. Phosphoinositide...

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TRPM2 cation channel regulates detrimental immune cell invasion in ischemic stroke

Mathias Gelderblom, Nico Melzer, Benjamin Schattling, Eva Göb, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 99

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The role of CCR6 in ischemic stroke

Priyadharshini Arunachalam, Mathias Gelderblom, Tim Magnus

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 135

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Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

Yi-Lin Cheng, Jong-Sung Park, Silvia Manzanero, Yuri Choi, more

Neurobiology of Disease > 2014 > 62 > Complete > 286-295

Recent findings suggest that Notch-1 signaling contributes to neuronal death in ischemic stroke, but the underlying mechanisms are unknown. Hypoxia inducible factor-1α (HIF-1α), a global regulator of cellular responses to hypoxia, can interact with Notch and modulate its signaling during hypoxic stress. Here we show that Notch signaling interacts with the HIF-1α pathway in the process of ischemic...

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Diagnostik polytoper Neuropathien

Mathias Gelderblom

InFo Neurologie & Psychiatrie > 2014 > 16 > 7-8 > 52-64

In der Diagnostik von Nervenläsionen ist die klinische Elektrophysiologie nach wie vor das zentrale diagnostische Instrument zur Ergänzung der klinisch-neurologischen Untersuchung. Als neu und diagnostisch wertvoll haben sich in den vergangenen Jahren die MR-Neurografie und die Nervensonografie erwiesen, die damit eine Erweiterung des traditionellen diagnostischen Repertoires darstellen.

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Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis

Mathias Gelderblom, Tristan Daehn, Benjamin Schattling, Peter Ludewig, more

Neurobiology of Disease > 2013 > 59 > Complete > 177-182

We aimed at validating a plasma biomarker for neuronal damage that can be used in acute and chronic models of neurological diseases.We investigated two different models, middle cerebral artery occlusion followed by reperfusion and MOG _35–55 -induced experimental autoimmune encephalomyelitis (EAE). In stroke experiments we measured infarct sizes by magnetic resonance imaging and vital stainings...

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Recovery from severe frontotemporal dysfunction at 3years after N-methyl-d-aspartic acid (NMDA) receptor antibody encephalitis

Frank Leypoldt, Mathias Gelderblom, Daniel Schöttle, Sascha Hoffmann, more

Journal of Clinical Neuroscience > 2013 > 20 > 4 > 611-613

Encephalitis associated with antibodies against N-methyl-d-aspartic acid (NMDA) receptor is characterized by severe memory deficits, decreased consciousness, epileptic seizures and movement disorders and occurs most commonly in young women. Recovery is mostly good but little is known about the disease course in patients whose treatment has been delayed severely. We present a 16-year-old girl with...

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Intravenous immunoglobulin protects neurons against amyloid beta‐peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

Alexander Widiapradja, Viktor Vegh, Ker Zhing Lok, Silvia Manzanero, more

Journal of Neurochemistry > 122 > 2 > 321 - 332

J. Neurochem. (2012) 122, 321–332. AbstractIntravenous immunoglobulin (IVIg) preparations obtained by fractionating blood plasma, are increasingly being used increasingly as an effective therapeutic agent in treatment of several inflammatory diseases. Its use as a potential therapeutic agent for treatment of stroke and Alzheimer’s disease has been proposed, but little is known about the neuroprotective...

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C5a Receptor (CD88) Inhibition Improves Hypothermia-Induced Neuroprotection in an In Vitro Ischemic Model

John Thundyil, Dale Pavlovski, Yu-Hsuan Hsieh, Mathias Gelderblom, more

NeuroMolecular Medicine > 2012 > 14 > 1 > 30-39

The concept of ‘salvageble penumbra’ has prompted both scientists and physicians to explore various neuroprotective approaches that could be beneficial during stroke therapy. Unfortunately, most of them have proved ineffective in targeting multiple cellular death cascades incited within the ischemic penumbra. Hypothermia has been shown to be capable of addressing this problem to some extent. Although...

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c-Jun N-terminal kinases (JNKs) and the cytoskeleton—functions beyond neurodegeneration

Mathias Gelderblom, Sevgi Eminel, Thomas Herdegen, Vicki Waetzig

International Journal of Developmental Neuroscience > 2004 > 22 > 7 > 559-564

The c-Jun N-terminal kinases (JNKs) are important mediators of neurodegeneration and their actions include the activation of genetic programs by phosphorylation of the nuclear transcription factor c-Jun/AP-1, the release of cytochrome c or the pro-inflammatory actions of microglia. Recent data, however, provide evidence for physiological functions of JNKs in particular JNK1, and this involves a role...

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Caspase-3 activation and DNA fragmentation in primary hippocampal neurons following glutamate excitotoxicity

Stephan Brecht, Mathias Gelderblom, Anu Srinivasan, Kirsten Mielke, more

Molecular Brain Research > 2001 > 94 > 1-2 > 25-34

Excitotoxic glutamate CNS stimulation can result in neuronal cell death. Contributing mechanisms and markers of cell death are the activation of caspase-3 and DNA fragmentation. It remains to be resolved to which extent both cellular reactions overlap and/or indicate different processes of neurodegeneration. In this study, mixed neuronal cultures from newborn mice pubs (0-24 h) were stimulated with...

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