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Firm T-lymphocyte binding to microvascular endothelium is an essential step during the early phases of inflammatory responses in skin. Dextrans have been demonstrated to affect lymphocyte-EC-interaction in vivo, however, the mechanisms involved remain unknown. Here we examined whether Dextran 40, a complex colloidal macromolecule widely used as an antithrombotic agent, affects T-lymphocyte-adhesion...