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The impact of Alzheimer's disease (AD) is projected to become one of the major challenges to modern society: over the next few years the incidence of AD will reach 1 million people in the UK alone with an estimated annual economic cost of £30 billion. Unfortunately, the existing diagnostic procedures are inadequate for early disease detection and do not always differentiate AD from other dementias...
Plasmonic-based biosensors offer huge potential as diagnostic instruments. The greatest benefit of such detection modalities is that they are label-free and thus only a single selective ligand is required for target detection, decreasing both protocol time and the required user proficiency. However, during technology development, the problems associated with using a detection system based upon an...
A disintegrin and metalloprotease (ADAM) proteins have wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion and intracellular signalling. Recent evidence suggests the involvement of ADAM8 in allergic responses. For instance, ADAM8 is amongst a number of genes up-regulated in experimentally induced asthma in animals. In order to further define...
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