The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Peri-conceptional folic acid supplementation has become a well established way to prevent neural tube defects (NTDs) and such supplementation reduces the prevalence of these defects by approximately 70%. However, the mechanism of the preventive effect of folic acid is not clear. This overview focuses on the biochemical basis of folic acid-preventable NTDs and on the results obtained with whole embryo...
In a previous paper (VanAerts et al., Toxicology in Vitro 1993, 7, 769-775) we have shown that the embryotoxicity of cyclophosphamide was greatly enhanced when cyclophosphamide had been added to a primary hepatocyte culture derived from Aroclor 1254-pretreated male rats (M A ) and the medium from this culture was added to a post-implantation rat embryo culture. However, when medium from hepatocytes...