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Experimental Allergic Encephalomyelitis (EAE) is the animal model of Multiple Sclerosis (MS), human chronic and progressive autoimmunological disease that lead to neurodegeneration in Central Nervous System (CNS). Although there are some hypothesis, like genetic, environmental or viral factors involvement, cause and patophysiology of MS remains still unknown, and that is the reason why there is no...
Experimental Allergic Encephalomyelitis (EAE) is the animal model of Multiple Sclerosis (MS), human autoimmunological disease that causes neurodegeneration. The autoimmune base of the disease leads to treatment searching in immunological mechanisms. Earlier we proposed the application of pig spinal cord hydrolysate as a mean to induce oral tolerance. The positive effects observed in EAE rats, stimulated...
EAE (Experimental Allergic Encephalomyelitis) is the animal model of Multiple Sclerosis, an autoimmune and neurodegenerative human disease. Proposed method for autoimmune diseases treatment is to evoke oral tolerance, which is lack of response to fed antigen. Our previous experiments showed that pig spinal cord hydrolysate, which is source of myelin antigens is able to evoke oral tolerance in EAE...
The aim of this study was to use the hydrolysate of pig spinal cord proteins to induce oral tolerance in the animal model of sclerosis multiplex experimental allergic encephalomyelitis. The female Lewis rats were fed with hydrolysate of pig spinal cord proteins in two doses for one week before immunization, which was induced by injection of guinea pig spinal cord homogenate. At the peak of clinical...
The aim of this study was to use the hydrolysate of pig spinal cord proteins to induce oral tolerance in the animal model of sclerosis multiplex - experimental allergic encephalomyelitis. The female Lewis rats were fed with hydrolysate of pig spinal cord proteins in two doses for one week before immunization, which was induced by injection of guinea pig spinal cord homogenate. At the peak of clinical...
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