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Computational prediction of cis-regulatory elements for a set of co-expressed genes based on sequence analysis provides an overwhelming volume of potential transcription factor binding sites. It presents a challenge to prioritize transcription factors for regulatory functional studies. A novel approach based on the use of Lasso regression models is proposed to address this problem. We examine the...
Pressure ulcer is a critical problem for bed-ridden and wheelchair-bound patients, diabetics, and the elderly. Patients need to be regularly repositioned to prevent excessive pressure on a single area of body, which can lead to ulcers. Pressure ulcers are costly to treat and cause many other health problems, including death. The current standard for prevention is to reposition at-risk patients every...
Confluent monolayers of cells in culture media are usually fragile and are susceptible to mechanical disruption. To assess the growth and migration of the cells towards recovery, the mechanical disruption is often done deliberately to perform wound healing assay. In such analysis, after a scratch in the cell monolayer, electrical characterization has been done to provide related quantitative description...
Collagen is believed to be one of the principal load bearing components of skin. This implies that deformation of collagen microfibrils play an important role in determining the extent of skin deformation under applied loads. We have developed a novel technique for generating internal strain maps of bundles of collagen microfibrils in the skin. The technique relies on digital image correlation (DIC)...
Debridement is referring to the removal of the grossly contaminated and devitalized soft tissue from the wounds in the meanwhile sparing the healthy tissue. With many types of debridement available nowadays, we can perform debridement using surgical, mechanical, enzymatic, autolytic and biosurgery method . Surgical debridement is considered the fastest and effective method to clean up a wound and...
This study aims to develop bioelectromanetic wound dressings to accelerate the healing of chronic wounds such as pressure ulcers. For this purpose the authors will carry out three different methods: nanolayered structures with metallic oxide elements, coated nanofiber bandages with metallic oxide elements and finally, bandages produced with knit structures integrating metallic yarns. The key concept...
Non-invasive visualization of wound bed with depth information is important to understand the tissue repair under therapeutic interventions. In this context, present study performs skin swept source-optical coherence tomography (i.e. optical biopsy/OCT) and correlates findings with histo-pathological observations on different types of traumatic non-healing wounds under honey dressing. Correlation...
This paper presents a Java framework for analyzing, processing and understanding wound images, to be used in teaching, learning and research activities. We intend to promote e-learning technologies in medical, pharmaceutical and health care domains. Using Java and XML technologies, we build models for various categories of wounds, due to various etiologies. Based on color and texture analysis, we...
Tactile sensation is important for the performance of daily tasks and prevention of injury. Full thickness wounds of greater than 4cm diameter will not spontaneously heal. Tissue engineering can be used to replace the lost skin, but this skin will often fail to be reinnervated. This results in loss of tactile sensations. Here we have developed a novel, silicon based MicroElectroMechanical Systems...
Tissue engineered skin constructed by cultured seed cells provides a new way to accelerate skin wound healing and improve the quality of tissue repair. Conventional models with dermal scaffold material based on collagen hydrogels, however, have poor stability and unsatisfactory longevity. Here, we describe an improved acellular amniotic membrane as a scafford with epidermal stem cells for tissue engineering...
β-catenin plays an important role in the tissue repair. But its expression and meanings in the diabetic cutaneous wound remains to be determined. In this study, we investigated the expression of β-catenin and PCNA in epidermal stem cells (ESCs) of diabetic rat skin. The diabetes mellitus (DM) rats were induced by a single i.p. injection of streptozotocin. ESCs were extracted from the dorsal skin samples...
Summary form only given. Atmospheric pressure air plasmas in direct contact with living tissue has been shown to have therapeutic effects in speeding the recovery of ulcerated skin and wounds. When dielectric barrier discharges (DBDs) are used for wound healing, the plasma device typically contains the powered electrode while the tissue is the counter electrode. The mechanism for wound healing is...
Summary form only given. This presentation provides a summary of current options of cold atmospheric plasma sources as intended for medical applications, in particular treatment of large infected skins. The summary is based on a common base of plasma-cell interactions but addressing the challenge of uneven and complex structures that are commonly found in human chronic wounds. Appropriate cold atmospheric...
Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of...
Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of...
Wound healing is a complex biological process dependent on multiple variables: tissue oxygenation, wound size, contamination, etc. Many of these factors depend on multiple factors themselves. Mechanisms for some interactions between these factors are still unknown but it is generally accepted that collagen synthesis, accumulation and organization are increased by mechanical stimuli, resulting in a...
The amniotic membranes have unique properties including transparency, stimulatory effect on cell proliferation and lack of immunogenicity, which may have clinical utility for cell delivery. In this chapter, we investigate the possibility of amniotic membranes loaded with bone marrow mesenchymal stem cells for healing of deep burn wound. The mesenchymal stem cells derived from human bone marrow were...
In an aging society, social demands for home-based rehabilitation and assistive technologies by healthcare and welfare services are globally increasing. The progress of quality-of-life technologies and rehabilitation science is a very important and urgent issue for elderly and disabled individuals as well as for their caregivers. Thus, there is a substantial need to develop simple bedside apparatuses...
Targeting wound repair, we developed an electrospun poly-L-lactide fibrous scaffold functionalized with G-CSF, a growth factor which is widely recognized as important in wound healing homeostasis. The scaffold was characterized in terms of morphology, mechanical properties and in vitro capacity to induce organization of co-cultures of murine fibroblasts and keratinocytes into a dermo-epidermal multilayered...
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