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To explore the nanoparticles-dependent signaling pathways is a rapidly growing research field. Here, we globally elucidate the regulation modules of cellular molecules by using graph-based representation of complex networks. We have packed some useful bioinformatics methods (Matlab Simbiology and Pathway Studio) into an integrated system for graph-based representation and complex networks modeling...
This work presents a customizable software framework that supports the analysis of correlations between genotype and phenotype within an integrated database in the context of metabolic disorders. The basis for the examination of relations between genotypes and phenotypes is the information from different life science data sources, merged by a mediator-based system in an integrated database. A graphical...
Genome-wide high-throughput mass spectrometry has emerged as an important new source of data on biological systems. This technology yields global information about the proteins expressed by an organism; consequently, biological processes can be studied without prior assumptions about the proteins that are involved. A profile of up- and down-regulated proteins is obtained which can be used to discover...
In proteomics, a proteinpsilas function is always strongly related to its structure. But, while some parts of a protein have a fixed definite structure, such as alpha-helix, beta-sheet, or coil, other parts are not associated with well-defined conformations. Previously, these so-called disordered regions were not thought to have a specific function of their own. But, recent studies suggest that some...
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